Pharmacokinetics, Tolerability, and Safety of Intranasal Administration of Reformulated OxyContin® Tablets Compared with Original OxyContin® Tablets in Healthy Adults

Background and Objective Reformulated OxyContin ® (oxycodone-HCl controlled release) tablets (ORF) became available in the United States in August 2010. The original formulation of OxyContin ® (oxycodone-HCl controlled release) tablets (OC) used a delivery system that did not provide inherent resist...

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Veröffentlicht in:	Clinical drug investigation 2013-06, Vol.33 (6), p.441-449
Hauptverfasser:	Perrino, Peter J., Colucci, Salvatore V., Apseloff, Glen, Harris, Stephen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analgesics, Opioid - pharmacokinetics Area Under Curve Delayed-Action Preparations Drug Delivery Systems Female Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Opioid-Related Disorders - prevention & control Original Original Research Article Oxycodone - administration & dosage Oxycodone - adverse effects Oxycodone - pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Single-Blind Method Tablets Young Adult
Online-Zugang:	Volltext
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