The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

RIP1 and RIP3 kinases are central players in TNF-induced programmed necrosis. Here, we report that the RIP homotypic interaction motifs (RHIMs) of RIP1 and RIP3 mediate the assembly of heterodimeric filamentous structures. The fibrils exhibit classical characteristics of β-amyloids, as shown by Thio...

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Veröffentlicht in:	Cell 2012-07, Vol.150 (2), p.339-350
Hauptverfasser:	Li, Jixi, McQuade, Thomas, Siemer, Ansgar B., Napetschnig, Johanna, Moriwaki, Kenta, Hsiao, Yu-Shan, Damko, Ermelinda, Moquin, David, Walz, Thomas, McDermott, Ann, Chan, Francis Ka-Ming, Wu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amyloid Amyloid - chemistry Humans infrared spectroscopy kinases Molecular Sequence Data mutation necrosis Necrosis - metabolism nuclear magnetic resonance spectroscopy phosphotransferases (kinases) Protein Interaction Domains and Motifs Receptor-Interacting Protein Serine-Threonine Kinases - chemistry Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Sequence Alignment Signal Transduction X-ray diffraction
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