HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life
Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to in...
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| Veröffentlicht in: | Mucosal immunology 2013-07, Vol.6 (4), p.692-703 |
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| creator | Yates, N L Stacey, A R Nolen, T L Vandergrift, N A Moody, M A Montefiori, D C Weinhold, K J Blattner, W A Borrow, P Shattock, R Cohen, M S Haynes, B F Tomaras, G D |
| description | Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I–VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a
t
1/2
of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life. |
| doi_str_mv | 10.1038/mi.2012.107 |
| format | Article |
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t
1/2
of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life.</description><identifier>ISSN: 1933-0219</identifier><identifier>EISSN: 1935-3456</identifier><identifier>DOI: 10.1038/mi.2012.107</identifier><identifier>PMID: 23299618</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/250/2152/2153 ; 631/250/347 ; 631/326/596/2563 ; 692/699/249/1570/1901 ; Allergology ; Antibodies ; Antibody Specificity - immunology ; B-Cell Activating Factor - metabolism ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Female ; Gastroenterology ; HIV Envelope Protein gp41 - immunology ; HIV Infections - immunology ; HIV Infections - metabolism ; HIV Infections - transmission ; HIV-1 - immunology ; Humans ; Immunity, Mucosal ; Immunoglobulin A - blood ; Immunoglobulin A - immunology ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; Immunology ; Lymphocyte Activation - immunology ; Male ; Time Factors</subject><ispartof>Mucosal immunology, 2013-07, Vol.6 (4), p.692-703</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Nature Publishing Group Jul 2013</rights><rights>Copyright © 2013 Society for Mucosal Immunology 2013 Society for Mucosal Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-2b7fbe89569483e69b8c299061eca826908bb4ae75a07df6c77eaeb08eb997b83</citedby><cites>FETCH-LOGICAL-c446t-2b7fbe89569483e69b8c299061eca826908bb4ae75a07df6c77eaeb08eb997b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23299618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yates, N L</creatorcontrib><creatorcontrib>Stacey, A R</creatorcontrib><creatorcontrib>Nolen, T L</creatorcontrib><creatorcontrib>Vandergrift, N A</creatorcontrib><creatorcontrib>Moody, M A</creatorcontrib><creatorcontrib>Montefiori, D C</creatorcontrib><creatorcontrib>Weinhold, K J</creatorcontrib><creatorcontrib>Blattner, W A</creatorcontrib><creatorcontrib>Borrow, P</creatorcontrib><creatorcontrib>Shattock, R</creatorcontrib><creatorcontrib>Cohen, M S</creatorcontrib><creatorcontrib>Haynes, B F</creatorcontrib><creatorcontrib>Tomaras, G D</creatorcontrib><title>HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life</title><title>Mucosal immunology</title><addtitle>Mucosal Immunol</addtitle><addtitle>Mucosal Immunol</addtitle><description>Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I–VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a
t
1/2
of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life.</description><subject>631/250/2152/2153</subject><subject>631/250/347</subject><subject>631/326/596/2563</subject><subject>692/699/249/1570/1901</subject><subject>Allergology</subject><subject>Antibodies</subject><subject>Antibody Specificity - immunology</subject><subject>B-Cell Activating Factor - metabolism</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>HIV Envelope Protein gp41 - immunology</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - metabolism</subject><subject>HIV Infections - transmission</subject><subject>HIV-1 - immunology</subject><subject>Humans</subject><subject>Immunity, Mucosal</subject><subject>Immunoglobulin A - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mucosal immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yates, N L</au><au>Stacey, A R</au><au>Nolen, T L</au><au>Vandergrift, N A</au><au>Moody, M A</au><au>Montefiori, D C</au><au>Weinhold, K J</au><au>Blattner, W A</au><au>Borrow, P</au><au>Shattock, R</au><au>Cohen, M S</au><au>Haynes, B F</au><au>Tomaras, G D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life</atitle><jtitle>Mucosal immunology</jtitle><stitle>Mucosal Immunol</stitle><addtitle>Mucosal Immunol</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>6</volume><issue>4</issue><spage>692</spage><epage>703</epage><pages>692-703</pages><issn>1933-0219</issn><eissn>1935-3456</eissn><abstract>Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I–VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a
t
1/2
of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>23299618</pmid><doi>10.1038/mi.2012.107</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Mucosal immunology, 2013-07, Vol.6 (4), p.692-703 |
| issn | 1933-0219 1935-3456 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 631/250/2152/2153 631/250/347 631/326/596/2563 692/699/249/1570/1901 Allergology Antibodies Antibody Specificity - immunology B-Cell Activating Factor - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedical and Life Sciences Biomedicine Female Gastroenterology HIV Envelope Protein gp41 - immunology HIV Infections - immunology HIV Infections - metabolism HIV Infections - transmission HIV-1 - immunology Humans Immunity, Mucosal Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunology Lymphocyte Activation - immunology Male Time Factors |
| title | HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life |
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