Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance
Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and development of peritendinous adhesions in the injured area. This study investigated the effect...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical science 2013-05, Vol.20 (1), p.28-28 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 28 |
|---|---|
| container_issue | 1 |
| container_start_page | 28 |
| container_title | Journal of biomedical science |
| container_volume | 20 |
| creator | Meimandi-Parizi, Abdolhamid Oryan, Ahmad Moshiri, Ali |
| description | Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and development of peritendinous adhesions in the injured area. This study investigated the effectiveness of a novel collagen implant on tendon healing in rabbits.
Seventy five mature White New-Zealand rabbits were divided into treated (n = 55) and control (n = 20) groups. The left Achilles tendon was completely transected and 2 cm excised. The defects of the treated animals were filled with collagen implants and repaired with sutures, but in control rabbits the defects were sutured similarly but the gap was left untreated. Changes in the injured and normal contralateral tendons were assessed weekly by measuring the diameter, temperature and bioelectrical characteristics of the injured area. Clinical examination was done and scored. Among the treated animals, small pilot groups were euthanized at 5, 10, 15, 20, 30, 40 and 60 (n = 5 at each time interval) and the remainder (n = 20) and the control animals at 120 days post injury (DPI). The lesions of all animals were examined at macroscopic and microscopic levels and the dry matter content, water delivery and water uptake characteristics of the lesions and normal contralateral tendons of both groups were analyzed at 120 DPI.
This novel collagen implant was biodegradable, biocompatible and possibly could be considered as a substitute for auto and allografts in clinical practice in near future. |
| doi_str_mv | 10.1186/1423-0127-20-28 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3663701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A534650686</galeid><sourcerecordid>A534650686</sourcerecordid><originalsourceid>FETCH-LOGICAL-b580t-7bcd548939909f3eaa6336b6b66a58a16c1839cce9c8840250ce1f316ac0c3233</originalsourceid><addsrcrecordid>eNqFkt9v1SAUxxujcXP67Jsh8cWXblBaCj6YXBd_JUtMjD4TSk9bFgpXoJv37_QfkubO62ZmDA_A4Xs-HPieonhO8CkhnJ2RuqIlJlVbVris-IPi-BB5eGt9VDyJ8RJj0gjePi6OKsraimJ6XPz84i0gP6BkYlwAgRuNAwjQI-2tVSM41KmYtymY3szgovFOWWTmrVUuIe9QmgBNoKxxIwoQt97FPTLH4ccWwpqWlLU7ZFy_6AyzKoyANnoy1kJECVyfQT0MoBOafQ_5AoeC6jqT4mukkPUZniDMKKal36FrkyY0mXFCOt9rdK4ogIUr5TQ8LR4NykZ4djOfFN_ev_t6_rG8-Pzh0_nmouwajlPZdrpvai6oEFgMFJRilLIuD6YargjThFOhNQjNeY2rBmsgAyVMaaxpRelJ8WbP3S7dDL3OjwzKym1-rwo76ZWRd0-cmeToryRljLaYZMDbPaAz_h-Auyfaz3I1Va6mygrLimfIq5sqgv--QExyNlFD9s6BX6IkTS0YxYLQ_0tzW9SC1PVa2su_pJd-Cdn4VdUwJljbNn9Uo7IgjRt8LlOvULlpaM0azDjLqtN7VHn0MBvtHQwmx-8knO0TdPAxBhgOX0KwXPv-nk94cduKg_53o9NfZZgBXQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1356696775</pqid></control><display><type>article</type><title>Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Meimandi-Parizi, Abdolhamid ; Oryan, Ahmad ; Moshiri, Ali</creator><creatorcontrib>Meimandi-Parizi, Abdolhamid ; Oryan, Ahmad ; Moshiri, Ali</creatorcontrib><description>Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and development of peritendinous adhesions in the injured area. This study investigated the effectiveness of a novel collagen implant on tendon healing in rabbits.
Seventy five mature White New-Zealand rabbits were divided into treated (n = 55) and control (n = 20) groups. The left Achilles tendon was completely transected and 2 cm excised. The defects of the treated animals were filled with collagen implants and repaired with sutures, but in control rabbits the defects were sutured similarly but the gap was left untreated. Changes in the injured and normal contralateral tendons were assessed weekly by measuring the diameter, temperature and bioelectrical characteristics of the injured area. Clinical examination was done and scored. Among the treated animals, small pilot groups were euthanized at 5, 10, 15, 20, 30, 40 and 60 (n = 5 at each time interval) and the remainder (n = 20) and the control animals at 120 days post injury (DPI). The lesions of all animals were examined at macroscopic and microscopic levels and the dry matter content, water delivery and water uptake characteristics of the lesions and normal contralateral tendons of both groups were analyzed at 120 DPI.
This novel collagen implant was biodegradable, biocompatible and possibly could be considered as a substitute for auto and allografts in clinical practice in near future.</description><identifier>ISSN: 1423-0127</identifier><identifier>ISSN: 1021-7770</identifier><identifier>EISSN: 1423-0127</identifier><identifier>DOI: 10.1186/1423-0127-20-28</identifier><identifier>PMID: 23672303</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Achilles Tendon - injuries ; Achilles Tendon - pathology ; Animals ; Architectural engineering ; Biocompatibility ; Biological products ; Cell culture ; Clinical medicine ; Collagen ; Collagen - chemistry ; Collagen - therapeutic use ; Defects ; Disease Models, Animal ; Humans ; Injuries ; Prostheses and Implants ; Rabbits ; Surgeons ; Surgical techniques ; Tendon Injuries - pathology ; Tendon Injuries - therapy ; Tendons ; Tissue Engineering ; Tissue Scaffolds ; Veterinary colleges ; Veterinary medicine ; Wound healing</subject><ispartof>Journal of biomedical science, 2013-05, Vol.20 (1), p.28-28</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Meimandi-Parizi et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Meimandi-Parizi et al.; licensee BioMed Central Ltd. 2013 Meimandi-Parizi et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b580t-7bcd548939909f3eaa6336b6b66a58a16c1839cce9c8840250ce1f316ac0c3233</citedby><cites>FETCH-LOGICAL-b580t-7bcd548939909f3eaa6336b6b66a58a16c1839cce9c8840250ce1f316ac0c3233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663701/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663701/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23672303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meimandi-Parizi, Abdolhamid</creatorcontrib><creatorcontrib>Oryan, Ahmad</creatorcontrib><creatorcontrib>Moshiri, Ali</creatorcontrib><title>Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance</title><title>Journal of biomedical science</title><addtitle>J Biomed Sci</addtitle><description>Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and development of peritendinous adhesions in the injured area. This study investigated the effectiveness of a novel collagen implant on tendon healing in rabbits.
Seventy five mature White New-Zealand rabbits were divided into treated (n = 55) and control (n = 20) groups. The left Achilles tendon was completely transected and 2 cm excised. The defects of the treated animals were filled with collagen implants and repaired with sutures, but in control rabbits the defects were sutured similarly but the gap was left untreated. Changes in the injured and normal contralateral tendons were assessed weekly by measuring the diameter, temperature and bioelectrical characteristics of the injured area. Clinical examination was done and scored. Among the treated animals, small pilot groups were euthanized at 5, 10, 15, 20, 30, 40 and 60 (n = 5 at each time interval) and the remainder (n = 20) and the control animals at 120 days post injury (DPI). The lesions of all animals were examined at macroscopic and microscopic levels and the dry matter content, water delivery and water uptake characteristics of the lesions and normal contralateral tendons of both groups were analyzed at 120 DPI.
This novel collagen implant was biodegradable, biocompatible and possibly could be considered as a substitute for auto and allografts in clinical practice in near future.</description><subject>Achilles Tendon - injuries</subject><subject>Achilles Tendon - pathology</subject><subject>Animals</subject><subject>Architectural engineering</subject><subject>Biocompatibility</subject><subject>Biological products</subject><subject>Cell culture</subject><subject>Clinical medicine</subject><subject>Collagen</subject><subject>Collagen - chemistry</subject><subject>Collagen - therapeutic use</subject><subject>Defects</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Injuries</subject><subject>Prostheses and Implants</subject><subject>Rabbits</subject><subject>Surgeons</subject><subject>Surgical techniques</subject><subject>Tendon Injuries - pathology</subject><subject>Tendon Injuries - therapy</subject><subject>Tendons</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><subject>Wound healing</subject><issn>1423-0127</issn><issn>1021-7770</issn><issn>1423-0127</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt9v1SAUxxujcXP67Jsh8cWXblBaCj6YXBd_JUtMjD4TSk9bFgpXoJv37_QfkubO62ZmDA_A4Xs-HPieonhO8CkhnJ2RuqIlJlVbVris-IPi-BB5eGt9VDyJ8RJj0gjePi6OKsraimJ6XPz84i0gP6BkYlwAgRuNAwjQI-2tVSM41KmYtymY3szgovFOWWTmrVUuIe9QmgBNoKxxIwoQt97FPTLH4ccWwpqWlLU7ZFy_6AyzKoyANnoy1kJECVyfQT0MoBOafQ_5AoeC6jqT4mukkPUZniDMKKal36FrkyY0mXFCOt9rdK4ogIUr5TQ8LR4NykZ4djOfFN_ev_t6_rG8-Pzh0_nmouwajlPZdrpvai6oEFgMFJRilLIuD6YargjThFOhNQjNeY2rBmsgAyVMaaxpRelJ8WbP3S7dDL3OjwzKym1-rwo76ZWRd0-cmeToryRljLaYZMDbPaAz_h-Auyfaz3I1Va6mygrLimfIq5sqgv--QExyNlFD9s6BX6IkTS0YxYLQ_0tzW9SC1PVa2su_pJd-Cdn4VdUwJljbNn9Uo7IgjRt8LlOvULlpaM0azDjLqtN7VHn0MBvtHQwmx-8knO0TdPAxBhgOX0KwXPv-nk94cduKg_53o9NfZZgBXQ</recordid><startdate>20130514</startdate><enddate>20130514</enddate><creator>Meimandi-Parizi, Abdolhamid</creator><creator>Oryan, Ahmad</creator><creator>Moshiri, Ali</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130514</creationdate><title>Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance</title><author>Meimandi-Parizi, Abdolhamid ; Oryan, Ahmad ; Moshiri, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b580t-7bcd548939909f3eaa6336b6b66a58a16c1839cce9c8840250ce1f316ac0c3233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Achilles Tendon - injuries</topic><topic>Achilles Tendon - pathology</topic><topic>Animals</topic><topic>Architectural engineering</topic><topic>Biocompatibility</topic><topic>Biological products</topic><topic>Cell culture</topic><topic>Clinical medicine</topic><topic>Collagen</topic><topic>Collagen - chemistry</topic><topic>Collagen - therapeutic use</topic><topic>Defects</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Injuries</topic><topic>Prostheses and Implants</topic><topic>Rabbits</topic><topic>Surgeons</topic><topic>Surgical techniques</topic><topic>Tendon Injuries - pathology</topic><topic>Tendon Injuries - therapy</topic><topic>Tendons</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds</topic><topic>Veterinary colleges</topic><topic>Veterinary medicine</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meimandi-Parizi, Abdolhamid</creatorcontrib><creatorcontrib>Oryan, Ahmad</creatorcontrib><creatorcontrib>Moshiri, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meimandi-Parizi, Abdolhamid</au><au>Oryan, Ahmad</au><au>Moshiri, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance</atitle><jtitle>Journal of biomedical science</jtitle><addtitle>J Biomed Sci</addtitle><date>2013-05-14</date><risdate>2013</risdate><volume>20</volume><issue>1</issue><spage>28</spage><epage>28</epage><pages>28-28</pages><issn>1423-0127</issn><issn>1021-7770</issn><eissn>1423-0127</eissn><abstract>Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and development of peritendinous adhesions in the injured area. This study investigated the effectiveness of a novel collagen implant on tendon healing in rabbits.
Seventy five mature White New-Zealand rabbits were divided into treated (n = 55) and control (n = 20) groups. The left Achilles tendon was completely transected and 2 cm excised. The defects of the treated animals were filled with collagen implants and repaired with sutures, but in control rabbits the defects were sutured similarly but the gap was left untreated. Changes in the injured and normal contralateral tendons were assessed weekly by measuring the diameter, temperature and bioelectrical characteristics of the injured area. Clinical examination was done and scored. Among the treated animals, small pilot groups were euthanized at 5, 10, 15, 20, 30, 40 and 60 (n = 5 at each time interval) and the remainder (n = 20) and the control animals at 120 days post injury (DPI). The lesions of all animals were examined at macroscopic and microscopic levels and the dry matter content, water delivery and water uptake characteristics of the lesions and normal contralateral tendons of both groups were analyzed at 120 DPI.
This novel collagen implant was biodegradable, biocompatible and possibly could be considered as a substitute for auto and allografts in clinical practice in near future.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23672303</pmid><doi>10.1186/1423-0127-20-28</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1423-0127 |
| ispartof | Journal of biomedical science, 2013-05, Vol.20 (1), p.28-28 |
| issn | 1423-0127 1021-7770 1423-0127 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3663701 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Achilles Tendon - injuries Achilles Tendon - pathology Animals Architectural engineering Biocompatibility Biological products Cell culture Clinical medicine Collagen Collagen - chemistry Collagen - therapeutic use Defects Disease Models, Animal Humans Injuries Prostheses and Implants Rabbits Surgeons Surgical techniques Tendon Injuries - pathology Tendon Injuries - therapy Tendons Tissue Engineering Tissue Scaffolds Veterinary colleges Veterinary medicine Wound healing |
| title | Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T12%3A27%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20tissue%20engineered%20collagen%20based%20tridimensional%20implant%20on%20the%20healing%20response%20of%20the%20experimentally%20induced%20large%20Achilles%20tendon%20defect%20model%20in%20rabbits:%20a%20long%20term%20study%20with%20high%20clinical%20relevance&rft.jtitle=Journal%20of%20biomedical%20science&rft.au=Meimandi-Parizi,%20Abdolhamid&rft.date=2013-05-14&rft.volume=20&rft.issue=1&rft.spage=28&rft.epage=28&rft.pages=28-28&rft.issn=1423-0127&rft.eissn=1423-0127&rft_id=info:doi/10.1186/1423-0127-20-28&rft_dat=%3Cgale_pubme%3EA534650686%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1356696775&rft_id=info:pmid/23672303&rft_galeid=A534650686&rfr_iscdi=true |