Factor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa

Factor (F) VIIIa forms a number of contacts with FIXa in assembling the FXase enzyme complex. Surface plasmon resonance was used to examine the interaction between immobilized biotinylated active site-modified FIXa, and FVIII and FVIIIa subunits. The FVIIIa A2 subunit bound FIXa with high affinity (...

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Veröffentlicht in:	The Journal of biological chemistry 2013-05, Vol.288 (21), p.15057-15064
Hauptverfasser:	Griffiths, Amy E, Rydkin, Ivan, Fay, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Factor IXa - chemistry Factor IXa - genetics Factor IXa - metabolism Factor VIIIa - chemistry Factor VIIIa - genetics Factor VIIIa - metabolism Humans Mutation, Missense Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Protein Binding Protein Folding Protein Structure and Folding Protein Structure, Tertiary
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