Characterization of adipose-derived stromal/stem cells from the Twitcher mouse model of Krabbe disease

Krabbe disease, also known as globoid cell leukodystrophy, is an autosomal recessive neurodegenerative disease caused by the genetic deficiency of galactocerebrosidase (GALC), a lysosomal enzyme responsible for the degradation of several glycosphingolipids like psychosine and galactosylceramide. In...

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Veröffentlicht in:	BMC cell biology 2013-04, Vol.14 (1), p.20-20, Article 20
Hauptverfasser:	Zhang, Xiujuan, Semon, Julie A, Zhang, Shijia, Strong, Amy L, Scruggs, Brittni A, Gimble, Jeffrey M, Bunnell, Bruce A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissues Analysis Animals Antigens, Surface - metabolism Biomedical research Bone marrow Cell Communication - physiology Cell culture Cell Differentiation - physiology Cells, Cultured Coculture Techniques Disease Models, Animal Enzymes Flow cytometry Galactosylceramidase - genetics Galactosylceramidase - metabolism Leukodystrophy, Globoid Cell - metabolism Leukodystrophy, Globoid Cell - pathology Leukodystrophy, Globoid Cell - physiopathology Lipids Macrophages - pathology Medical research Medicine Medicine, Experimental Mice Mice, Mutant Strains Mutation - genetics Nervous system diseases Osteogenesis - physiology Stem cells Stem Cells - metabolism Stem Cells - pathology Stromal Cells - metabolism Stromal Cells - pathology Subcutaneous Fat - metabolism Subcutaneous Fat - pathology Subcutaneous Fat - physiopathology Transplantation Transplants & implants
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