The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice

Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors compromise islet survival, including recurrent diabetes. We investigated whether CD39, an ectonucleotidase that promotes the generation of extracell...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2013-06, Vol.62 (6), p.2026-2035
Hauptverfasser:	CHIA, Joanne S. J, McRAE, Jennifer L, COWAN, Peter J, DWYER, Karen M, THOMAS, Helen E, FYNCH, Stacey, ELKERBOUT, Lorraine, HILL, Prue, MURRAY-SEGAL, Lisa, ROBSON, Simon C, CHEN, Jiang-Fan, D'APICE, Anthony J. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Analysis Animals Antigens, CD - genetics Antigens, CD - metabolism Apyrase - genetics Apyrase - metabolism Autoimmune diseases Biological and medical sciences Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Flow Cytometry Gene expression Immunohistochemistry Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Neutrophils Original Research Real-Time Polymerase Chain Reaction Receptors, Purinergic P1 - genetics Receptors, Purinergic P1 - metabolism
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