Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch
Summary Background Patients with central centrifugal cicatricial alopecia (CCCA) often suffer from varying degrees of itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed. Objective To conduct a comprehensive analysis of C nerve fibre func...
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| Veröffentlicht in: | British journal of dermatology (1951) 2013-02, Vol.168 (2), p.253-256 |
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| container_title | British journal of dermatology (1951) |
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| creator | Bin Saif, G.A. McMichael, A. Kwatra, S.G. Chan, Y.-H. Yosipovitch, G. |
| description | Summary
Background Patients with central centrifugal cicatricial alopecia (CCCA) often suffer from varying degrees of itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
Objective To conduct a comprehensive analysis of C nerve fibre function relating to itch and pain perception in patients with CCCA using thermosensory testing and experimental itch models.
Methods Fifteen healthy African‐American women and 16 African‐American female patients with CCCA participated in the study and underwent quantitative computerized thermosensory testing to assess warmth and heat pain thresholds. Itch was induced using histamine iontophoresis and application of cowhage spicules, and the intensity of each itch was assessed. The association between itch intensity and CCCA severity score was examined.
Results A positive correlation between CCCA severity score and peak itch ratings of cowhage on the lesional scalp (crown) was observed (P = 0·023, r = 0·562). Notably, the histamine peak itch rating was not found to have a significant correlation with CCCA severity score (P = 0·913). The crown also had significantly higher warmth and pain thresholds than the occiput in both healthy subjects and patients with CCCA.
Conclusions Our results suggest a putative role for the protease‐activated receptor (PAR)‐2, which is activated by cowhage, in the pathogenesis of CCCA. Future studies should examine PAR‐2‐directed therapeutics for patients with CCCA. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.
What’s already known about this topic?
•
Patients with central centrifugal cicatricial alopecia (CCCA) often complain of intense itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
What does this study add?
•
This study demonstrates a significant correlation between cowhage‐induced itch intensity and the severity of CCCA.
•
As cowhage signals through the protease‐activated receptor (PAR)‐2, these results suggest a putative role for the PAR‐2 pathway in CCCA‐associated skin sensation. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity. |
| doi_str_mv | 10.1111/bjd.12043 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3659809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1283728672</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4833-fd999ff5264dc125370410343c0e438e747e8fc70202ab22ef0d6b256fca0e373</originalsourceid><addsrcrecordid>eNp1kU1vEzEQhi0EoqHlwB9Ae0Eqh23HH7teX5AgQKFEhQOo4mQ53nHistlN7d2G_HscNg1wwJcZj5-Z1zNDyDMKZzSd8_lNfUYZCP6ATCgvi5xRzh-SCQDIHFTJj8iTGG8AKIcCHpMjxlRVCOAT8n2KbR9Mk9md9W5Y7HxvTbpYn3zTdGtMXhbxDoPvt5mPmYmxS7Ee62zj-2Vmu83SLDD3bT3YFPS9XZ6QR840EZ_u7TH59v7d1-mHfPb54uP09Sy3ouI8d7VSyrmClaK2lBVcgqDABbeAglcohcTKWQkMmJkzhg7qcs6K0lkDyCU_Jq_GuuthvsLajv3odfArE7a6M17_-9L6pV50dzoNSlWgUoHTfYHQ3Q4Ye73y0WLTmBa7IWrKKi5ZVUqW0JcjakMXY0B3kKGgd6vQaRX69yoS-_zvfx3I-9kn4MUeMNGaxgXTWh__cKllpdhO9HzkNr7B7f8V9ZvLt_fS-ZjhY48_Dxkm_NCl5LLQ11cX-np2-eVTKYQu-S_is7AV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1283728672</pqid></control><display><type>article</type><title>Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bin Saif, G.A. ; McMichael, A. ; Kwatra, S.G. ; Chan, Y.-H. ; Yosipovitch, G.</creator><creatorcontrib>Bin Saif, G.A. ; McMichael, A. ; Kwatra, S.G. ; Chan, Y.-H. ; Yosipovitch, G.</creatorcontrib><description>Summary
Background Patients with central centrifugal cicatricial alopecia (CCCA) often suffer from varying degrees of itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
Objective To conduct a comprehensive analysis of C nerve fibre function relating to itch and pain perception in patients with CCCA using thermosensory testing and experimental itch models.
Methods Fifteen healthy African‐American women and 16 African‐American female patients with CCCA participated in the study and underwent quantitative computerized thermosensory testing to assess warmth and heat pain thresholds. Itch was induced using histamine iontophoresis and application of cowhage spicules, and the intensity of each itch was assessed. The association between itch intensity and CCCA severity score was examined.
Results A positive correlation between CCCA severity score and peak itch ratings of cowhage on the lesional scalp (crown) was observed (P = 0·023, r = 0·562). Notably, the histamine peak itch rating was not found to have a significant correlation with CCCA severity score (P = 0·913). The crown also had significantly higher warmth and pain thresholds than the occiput in both healthy subjects and patients with CCCA.
Conclusions Our results suggest a putative role for the protease‐activated receptor (PAR)‐2, which is activated by cowhage, in the pathogenesis of CCCA. Future studies should examine PAR‐2‐directed therapeutics for patients with CCCA. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.
What’s already known about this topic?
•
Patients with central centrifugal cicatricial alopecia (CCCA) often complain of intense itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
What does this study add?
•
This study demonstrates a significant correlation between cowhage‐induced itch intensity and the severity of CCCA.
•
As cowhage signals through the protease‐activated receptor (PAR)‐2, these results suggest a putative role for the PAR‐2 pathway in CCCA‐associated skin sensation. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/bjd.12043</identifier><identifier>PMID: 22985403</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; African Americans ; Alopecia - etiology ; Biological and medical sciences ; Case-Control Studies ; Dermatology ; Female ; Hair and nails disorders ; Histamine - pharmacology ; Hot Temperature ; Humans ; Iontophoresis - methods ; Medical sciences ; Middle Aged ; Mucuna - physiology ; Nerve Fibers, Unmyelinated - physiology ; Pain Perception - drug effects ; Pain Threshold - drug effects ; Pruritus - etiology ; Severity of Illness Index ; Young Adult</subject><ispartof>British journal of dermatology (1951), 2013-02, Vol.168 (2), p.253-256</ispartof><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists</rights><rights>2014 INIST-CNRS</rights><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists.</rights><rights>2012 The Authors 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4833-fd999ff5264dc125370410343c0e438e747e8fc70202ab22ef0d6b256fca0e373</citedby><cites>FETCH-LOGICAL-c4833-fd999ff5264dc125370410343c0e438e747e8fc70202ab22ef0d6b256fca0e373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjd.12043$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjd.12043$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27029922$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22985403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bin Saif, G.A.</creatorcontrib><creatorcontrib>McMichael, A.</creatorcontrib><creatorcontrib>Kwatra, S.G.</creatorcontrib><creatorcontrib>Chan, Y.-H.</creatorcontrib><creatorcontrib>Yosipovitch, G.</creatorcontrib><title>Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Patients with central centrifugal cicatricial alopecia (CCCA) often suffer from varying degrees of itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
Objective To conduct a comprehensive analysis of C nerve fibre function relating to itch and pain perception in patients with CCCA using thermosensory testing and experimental itch models.
Methods Fifteen healthy African‐American women and 16 African‐American female patients with CCCA participated in the study and underwent quantitative computerized thermosensory testing to assess warmth and heat pain thresholds. Itch was induced using histamine iontophoresis and application of cowhage spicules, and the intensity of each itch was assessed. The association between itch intensity and CCCA severity score was examined.
Results A positive correlation between CCCA severity score and peak itch ratings of cowhage on the lesional scalp (crown) was observed (P = 0·023, r = 0·562). Notably, the histamine peak itch rating was not found to have a significant correlation with CCCA severity score (P = 0·913). The crown also had significantly higher warmth and pain thresholds than the occiput in both healthy subjects and patients with CCCA.
Conclusions Our results suggest a putative role for the protease‐activated receptor (PAR)‐2, which is activated by cowhage, in the pathogenesis of CCCA. Future studies should examine PAR‐2‐directed therapeutics for patients with CCCA. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.
What’s already known about this topic?
•
Patients with central centrifugal cicatricial alopecia (CCCA) often complain of intense itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
What does this study add?
•
This study demonstrates a significant correlation between cowhage‐induced itch intensity and the severity of CCCA.
•
As cowhage signals through the protease‐activated receptor (PAR)‐2, these results suggest a putative role for the PAR‐2 pathway in CCCA‐associated skin sensation. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.</description><subject>Adult</subject><subject>African Americans</subject><subject>Alopecia - etiology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Dermatology</subject><subject>Female</subject><subject>Hair and nails disorders</subject><subject>Histamine - pharmacology</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Iontophoresis - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucuna - physiology</subject><subject>Nerve Fibers, Unmyelinated - physiology</subject><subject>Pain Perception - drug effects</subject><subject>Pain Threshold - drug effects</subject><subject>Pruritus - etiology</subject><subject>Severity of Illness Index</subject><subject>Young Adult</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1vEzEQhi0EoqHlwB9Ae0Eqh23HH7teX5AgQKFEhQOo4mQ53nHistlN7d2G_HscNg1wwJcZj5-Z1zNDyDMKZzSd8_lNfUYZCP6ATCgvi5xRzh-SCQDIHFTJj8iTGG8AKIcCHpMjxlRVCOAT8n2KbR9Mk9md9W5Y7HxvTbpYn3zTdGtMXhbxDoPvt5mPmYmxS7Ee62zj-2Vmu83SLDD3bT3YFPS9XZ6QR840EZ_u7TH59v7d1-mHfPb54uP09Sy3ouI8d7VSyrmClaK2lBVcgqDABbeAglcohcTKWQkMmJkzhg7qcs6K0lkDyCU_Jq_GuuthvsLajv3odfArE7a6M17_-9L6pV50dzoNSlWgUoHTfYHQ3Q4Ye73y0WLTmBa7IWrKKi5ZVUqW0JcjakMXY0B3kKGgd6vQaRX69yoS-_zvfx3I-9kn4MUeMNGaxgXTWh__cKllpdhO9HzkNr7B7f8V9ZvLt_fS-ZjhY48_Dxkm_NCl5LLQ11cX-np2-eVTKYQu-S_is7AV</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Bin Saif, G.A.</creator><creator>McMichael, A.</creator><creator>Kwatra, S.G.</creator><creator>Chan, Y.-H.</creator><creator>Yosipovitch, G.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201302</creationdate><title>Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch</title><author>Bin Saif, G.A. ; McMichael, A. ; Kwatra, S.G. ; Chan, Y.-H. ; Yosipovitch, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4833-fd999ff5264dc125370410343c0e438e747e8fc70202ab22ef0d6b256fca0e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Alopecia - etiology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Dermatology</topic><topic>Female</topic><topic>Hair and nails disorders</topic><topic>Histamine - pharmacology</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Iontophoresis - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mucuna - physiology</topic><topic>Nerve Fibers, Unmyelinated - physiology</topic><topic>Pain Perception - drug effects</topic><topic>Pain Threshold - drug effects</topic><topic>Pruritus - etiology</topic><topic>Severity of Illness Index</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bin Saif, G.A.</creatorcontrib><creatorcontrib>McMichael, A.</creatorcontrib><creatorcontrib>Kwatra, S.G.</creatorcontrib><creatorcontrib>Chan, Y.-H.</creatorcontrib><creatorcontrib>Yosipovitch, G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bin Saif, G.A.</au><au>McMichael, A.</au><au>Kwatra, S.G.</au><au>Chan, Y.-H.</au><au>Yosipovitch, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2013-02</date><risdate>2013</risdate><volume>168</volume><issue>2</issue><spage>253</spage><epage>256</epage><pages>253-256</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Patients with central centrifugal cicatricial alopecia (CCCA) often suffer from varying degrees of itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
Objective To conduct a comprehensive analysis of C nerve fibre function relating to itch and pain perception in patients with CCCA using thermosensory testing and experimental itch models.
Methods Fifteen healthy African‐American women and 16 African‐American female patients with CCCA participated in the study and underwent quantitative computerized thermosensory testing to assess warmth and heat pain thresholds. Itch was induced using histamine iontophoresis and application of cowhage spicules, and the intensity of each itch was assessed. The association between itch intensity and CCCA severity score was examined.
Results A positive correlation between CCCA severity score and peak itch ratings of cowhage on the lesional scalp (crown) was observed (P = 0·023, r = 0·562). Notably, the histamine peak itch rating was not found to have a significant correlation with CCCA severity score (P = 0·913). The crown also had significantly higher warmth and pain thresholds than the occiput in both healthy subjects and patients with CCCA.
Conclusions Our results suggest a putative role for the protease‐activated receptor (PAR)‐2, which is activated by cowhage, in the pathogenesis of CCCA. Future studies should examine PAR‐2‐directed therapeutics for patients with CCCA. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.
What’s already known about this topic?
•
Patients with central centrifugal cicatricial alopecia (CCCA) often complain of intense itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
What does this study add?
•
This study demonstrates a significant correlation between cowhage‐induced itch intensity and the severity of CCCA.
•
As cowhage signals through the protease‐activated receptor (PAR)‐2, these results suggest a putative role for the PAR‐2 pathway in CCCA‐associated skin sensation. Examining for itch and other dysaesthesias in patients with CCCA is of vital importance to dermatologists in assessing disease severity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22985403</pmid><doi>10.1111/bjd.12043</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of dermatology (1951), 2013-02, Vol.168 (2), p.253-256 |
| issn | 0007-0963 1365-2133 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult African Americans Alopecia - etiology Biological and medical sciences Case-Control Studies Dermatology Female Hair and nails disorders Histamine - pharmacology Hot Temperature Humans Iontophoresis - methods Medical sciences Middle Aged Mucuna - physiology Nerve Fibers, Unmyelinated - physiology Pain Perception - drug effects Pain Threshold - drug effects Pruritus - etiology Severity of Illness Index Young Adult |
| title | Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch |
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