Resolvin D2 restores neutrophil directionality and improves survival after burns
Following severe burns and trauma injuries, the changes of neutrophil migratory phenotype are a double‐edged sword. Activated neutrophils migrate into injured tissues and help contain microbial infections, but they can also enter normal tissues and damage vital organs. Depleting the neutrophils from...
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| Veröffentlicht in: | The FASEB journal 2013-06, Vol.27 (6), p.2270-2281 |
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| creator | Kurihara, Tomohiro Jones, Caroline N. Yu, Yong‐Ming Fischman, Alan J. Watada, Susumu Tompkins, Ronald G. Fagan, Shawn P. Irimia, Daniel |
| description | Following severe burns and trauma injuries, the changes of neutrophil migratory phenotype are a double‐edged sword. Activated neutrophils migrate into injured tissues and help contain microbial infections, but they can also enter normal tissues and damage vital organs. Depleting the neutrophils from circulation protects vital organs against neutrophil‐induced damage but leaves the body exposed to infectious complications. Here we show that restoring normal neutrophil migratory phenotype in rats with burn injuries correlates with improved survival in a classical double‐injury model of sequential burn and septic insults. We uncovered that the directionality of neutrophils from burned rats can be restored both in vitro by 1 nM resolvin D2 (RvD2) and in vivo by RvD2 for 7 d, 25 ng/kg body mass (8–10 ng/rat). Restoring neutrophil directionality dramatically increases survival after a second septic insult at d 9 postburn. Survival of RvD2‐treated animals increases from 0 to 100% after lipopolysaccharide injection and is extended by 1 wk after cecal ligation. Survival does not significantly increase when the restoration of neutrophil directionality is incomplete, following shorter regimens of RvD2. We conclude that restoring neutrophil directionality using RvD2 could have prophylactic value and delay lethal complications after burn injuries.—Kurihara T., Jones, C. N., Yu, Y.‐M., Fischman, A. J., Watada, S., Tompkins, R. G., Fagan, S. P., Irimia, D. Resolvin D2 restores neutrophil directionality and improves survival after burns. FASEB J. 27, 2270–2281 (2013). www.fasebj.org |
| doi_str_mv | 10.1096/fj.12-219519 |
| format | Article |
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Activated neutrophils migrate into injured tissues and help contain microbial infections, but they can also enter normal tissues and damage vital organs. Depleting the neutrophils from circulation protects vital organs against neutrophil‐induced damage but leaves the body exposed to infectious complications. Here we show that restoring normal neutrophil migratory phenotype in rats with burn injuries correlates with improved survival in a classical double‐injury model of sequential burn and septic insults. We uncovered that the directionality of neutrophils from burned rats can be restored both in vitro by 1 nM resolvin D2 (RvD2) and in vivo by RvD2 for 7 d, 25 ng/kg body mass (8–10 ng/rat). Restoring neutrophil directionality dramatically increases survival after a second septic insult at d 9 postburn. Survival of RvD2‐treated animals increases from 0 to 100% after lipopolysaccharide injection and is extended by 1 wk after cecal ligation. Survival does not significantly increase when the restoration of neutrophil directionality is incomplete, following shorter regimens of RvD2. We conclude that restoring neutrophil directionality using RvD2 could have prophylactic value and delay lethal complications after burn injuries.—Kurihara T., Jones, C. N., Yu, Y.‐M., Fischman, A. J., Watada, S., Tompkins, R. G., Fagan, S. P., Irimia, D. Resolvin D2 restores neutrophil directionality and improves survival after burns. 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Activated neutrophils migrate into injured tissues and help contain microbial infections, but they can also enter normal tissues and damage vital organs. Depleting the neutrophils from circulation protects vital organs against neutrophil‐induced damage but leaves the body exposed to infectious complications. Here we show that restoring normal neutrophil migratory phenotype in rats with burn injuries correlates with improved survival in a classical double‐injury model of sequential burn and septic insults. We uncovered that the directionality of neutrophils from burned rats can be restored both in vitro by 1 nM resolvin D2 (RvD2) and in vivo by RvD2 for 7 d, 25 ng/kg body mass (8–10 ng/rat). Restoring neutrophil directionality dramatically increases survival after a second septic insult at d 9 postburn. Survival of RvD2‐treated animals increases from 0 to 100% after lipopolysaccharide injection and is extended by 1 wk after cecal ligation. Survival does not significantly increase when the restoration of neutrophil directionality is incomplete, following shorter regimens of RvD2. We conclude that restoring neutrophil directionality using RvD2 could have prophylactic value and delay lethal complications after burn injuries.—Kurihara T., Jones, C. N., Yu, Y.‐M., Fischman, A. J., Watada, S., Tompkins, R. G., Fagan, S. P., Irimia, D. Resolvin D2 restores neutrophil directionality and improves survival after burns. FASEB J. 27, 2270–2281 (2013). www.fasebj.org</description><subject>Animals</subject><subject>Burns - complications</subject><subject>Burns - drug therapy</subject><subject>Burns - physiopathology</subject><subject>chemotaxis</subject><subject>Chemotaxis, Leukocyte - drug effects</subject><subject>Chemotaxis, Leukocyte - physiology</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Docosahexaenoic Acids - physiology</subject><subject>inflammation</subject><subject>innate immunity</subject><subject>lipid mediators</subject><subject>Male</subject><subject>microfluidics</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Research Communications</subject><subject>Sepsis - complications</subject><subject>Sepsis - drug therapy</subject><subject>Sepsis - physiopathology</subject><issn>0892-6638</issn><issn>1530-6860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhxhnlyIGUsR1_XZBooYBUCcTH2XKcMfXKGy92ErT_nlRbKrjAZeYwjx7NzEvIUwpnFIx8GbZnlLWMGkHNPbKhgkMrtYT7ZAPasFZKrk_Io1q3AECByofkhPGOg1F6Qz59xprTEsfmDWsK1imvpRlxnkreX8fUDLGgn2IeXYrToXHj0MTdvuRlxepclri41LgwYWn6uYz1MXkQXKr45Lafkm-Xb79evG-vPr77cPH6qvWdFLplwfReSh3AU6md6VynvUA0Q-cAvMbOCTX0gwDd-x61CU4FpjSnigujkJ-SV0fvfu53OHgcp-KS3Ze4c-Vgs4v278kYr-33vFguheFCroLnt4KSf8zr5XYXq8eU3Ih5rpYKQdfXCYD_o1yozmja3aAvjqgvudaC4W4jCvYmLxu2ljJ7zGvFn_15xR38O6AVUEfgZ0x4-KfMXn45Z8AUgASq-S99k6L1</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Kurihara, Tomohiro</creator><creator>Jones, Caroline N.</creator><creator>Yu, Yong‐Ming</creator><creator>Fischman, Alan J.</creator><creator>Watada, Susumu</creator><creator>Tompkins, Ronald G.</creator><creator>Fagan, Shawn P.</creator><creator>Irimia, Daniel</creator><general>Federation of American Societies for Experimental Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201306</creationdate><title>Resolvin D2 restores neutrophil directionality and improves survival after burns</title><author>Kurihara, Tomohiro ; Jones, Caroline N. ; Yu, Yong‐Ming ; Fischman, Alan J. ; Watada, Susumu ; Tompkins, Ronald G. ; Fagan, Shawn P. ; Irimia, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4658-2f9bc668f0c168a94a48c5ee9d4a00c8e4a57dbd508bcbe89fa7f2783173597e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Burns - complications</topic><topic>Burns - drug therapy</topic><topic>Burns - physiopathology</topic><topic>chemotaxis</topic><topic>Chemotaxis, Leukocyte - drug effects</topic><topic>Chemotaxis, Leukocyte - physiology</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Docosahexaenoic Acids - physiology</topic><topic>inflammation</topic><topic>innate immunity</topic><topic>lipid mediators</topic><topic>Male</topic><topic>microfluidics</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Research Communications</topic><topic>Sepsis - complications</topic><topic>Sepsis - drug therapy</topic><topic>Sepsis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurihara, Tomohiro</creatorcontrib><creatorcontrib>Jones, Caroline N.</creatorcontrib><creatorcontrib>Yu, Yong‐Ming</creatorcontrib><creatorcontrib>Fischman, Alan J.</creatorcontrib><creatorcontrib>Watada, Susumu</creatorcontrib><creatorcontrib>Tompkins, Ronald G.</creatorcontrib><creatorcontrib>Fagan, Shawn P.</creatorcontrib><creatorcontrib>Irimia, Daniel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The FASEB journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurihara, Tomohiro</au><au>Jones, Caroline N.</au><au>Yu, Yong‐Ming</au><au>Fischman, Alan J.</au><au>Watada, Susumu</au><au>Tompkins, Ronald G.</au><au>Fagan, Shawn P.</au><au>Irimia, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resolvin D2 restores neutrophil directionality and improves survival after burns</atitle><jtitle>The FASEB journal</jtitle><addtitle>FASEB J</addtitle><date>2013-06</date><risdate>2013</risdate><volume>27</volume><issue>6</issue><spage>2270</spage><epage>2281</epage><pages>2270-2281</pages><issn>0892-6638</issn><eissn>1530-6860</eissn><abstract>Following severe burns and trauma injuries, the changes of neutrophil migratory phenotype are a double‐edged sword. Activated neutrophils migrate into injured tissues and help contain microbial infections, but they can also enter normal tissues and damage vital organs. Depleting the neutrophils from circulation protects vital organs against neutrophil‐induced damage but leaves the body exposed to infectious complications. Here we show that restoring normal neutrophil migratory phenotype in rats with burn injuries correlates with improved survival in a classical double‐injury model of sequential burn and septic insults. We uncovered that the directionality of neutrophils from burned rats can be restored both in vitro by 1 nM resolvin D2 (RvD2) and in vivo by RvD2 for 7 d, 25 ng/kg body mass (8–10 ng/rat). Restoring neutrophil directionality dramatically increases survival after a second septic insult at d 9 postburn. Survival of RvD2‐treated animals increases from 0 to 100% after lipopolysaccharide injection and is extended by 1 wk after cecal ligation. 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| subjects | Animals Burns - complications Burns - drug therapy Burns - physiopathology chemotaxis Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - physiology Docosahexaenoic Acids - pharmacology Docosahexaenoic Acids - physiology inflammation innate immunity lipid mediators Male microfluidics Neutrophils - drug effects Neutrophils - physiology Rats Rats, Wistar Research Communications Sepsis - complications Sepsis - drug therapy Sepsis - physiopathology |
| title | Resolvin D2 restores neutrophil directionality and improves survival after burns |
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