Effects of Bisphosphonate Treatment on Circulating Osteogenic Endothelial Progenitor Cells in Postmenopausal Women

Abstract Objective To evaluate whether bisphosphonates modulate vascular calcification by a modification in endothelial progenitor cells (EPCs) coexpressing osteoblastic surface markers and genes. Patients and Methods We performed a double-blind, randomized study of 20 healthy, early postmenopausal...

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Veröffentlicht in:	Mayo Clinic proceedings 2013-01, Vol.88 (1), p.46-55
Hauptverfasser:	Peris, Pilar, MD, Atkinson, Elizabeth J., MS, Gössl, Mario, MD, Kane, Trevor L., BS, McCready, Louise K., RN, Lerman, Amir, MD, Khosla, Sundeep, MD, McGregor, Ulrike I., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - blood Bone Density - drug effects Bone Density Conservation Agents - therapeutic use C-Reactive Protein - metabolism Calcification Calcium - blood Complications and side effects Creatinine - blood Diphosphonates Dosage and administration Double-Blind Method Down-Regulation Endothelium - cytology Endothelium - drug effects Endothelium - metabolism Enzyme-Linked Immunosorbent Assay Etidronic Acid - analogs & derivatives Etidronic Acid - therapeutic use Female Flow Cytometry Gene Expression Regulation - drug effects Genetic aspects Humans Interleukin-8 - blood Internal Medicine Middle Aged Osteoblasts - metabolism Osteogenesis - drug effects Osteoporosis, Postmenopausal - drug therapy Osteoporosis, Postmenopausal - genetics Osteoprotegerin - blood Phosphorus - blood Physiological aspects Placebos RANK Ligand - blood Risedronic Acid Risk factors Stem cells Stem Cells - drug effects Stem Cells - metabolism Treatment Outcome Vitamin D - blood
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