A prospective study of plasma inflammatory markers and risk of colorectal cancer in men
Background: Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent. Methods: We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the...
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| Veröffentlicht in: | British journal of cancer 2013-05, Vol.108 (9), p.1891-1898 |
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| creator | Song, M Wu, K Ogino, S Fuchs, C S Giovannucci, E L Chan, A T |
| description | Background:
Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent.
Methods:
We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study.
Results:
Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99–2.40;
P
trend
=0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78–2.05;
P
trend
=0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (
P
interaction
=0.03). We did not observe any significant association between CRP or sTNFR-2 and CRC.
Conclusion:
Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation. |
| doi_str_mv | 10.1038/bjc.2013.172 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3658520</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1356931971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c579t-237c4bc3cbdfd8e9fd4b95242b6a0b1d763dcc5bdc44ebe7c6532657088480bf3</originalsourceid><addsrcrecordid>eNqNkc1rFDEYh4NY7Fq9eZaACB6cNR-TSXIRSrG1UPCieAz5mjrbTDImM4X9781219qKB08h5Hl_7_vmAeAVRmuMqPhgNnZNEKZrzMkTsMKMkgYLwp-CFUKIN0gSdAyel7KpV4kEfwaOCWUSY0lW4PspnHIqk7fzcOthmRe3hamHU9Bl1HCIfdDjqOeUt3DU-cbnAnV0MA_lZsfZFFKuxTpAq6P1uZbA0ccX4KjXofiXh_MEfDv_9PXsc3P15eLy7PSqsYzLuSGU29ZYao3rnfCyd62RjLTEdBoZ7HhHnbXMONu23nhuu7pexzgSohXI9PQEfNznTosZvbM-zlkHNeWhTrtVSQ_q8UscfqjrdKtoxwQjqAa8OwTk9HPxZVbjUKwPQUeflqIwZZ2kWHL8PyghXDDEKvrmL3STlhzrT-woJDGvsZV6v6dsVVCy7-_nxkjt5KoqV-3kqiq34q8f7noP_7ZZgbcHQBerQ5-rkaH84WpTLu-4Zs-V-hSvfX4w3b8a_wKVhrxN</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1350917356</pqid></control><display><type>article</type><title>A prospective study of plasma inflammatory markers and risk of colorectal cancer in men</title><source>MEDLINE</source><source>Nature</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Song, M ; Wu, K ; Ogino, S ; Fuchs, C S ; Giovannucci, E L ; Chan, A T</creator><creatorcontrib>Song, M ; Wu, K ; Ogino, S ; Fuchs, C S ; Giovannucci, E L ; Chan, A T</creatorcontrib><description>Background:
Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent.
Methods:
We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study.
Results:
Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99–2.40;
P
trend
=0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78–2.05;
P
trend
=0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (
P
interaction
=0.03). We did not observe any significant association between CRP or sTNFR-2 and CRC.
Conclusion:
Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2013.172</identifier><identifier>PMID: 23591192</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/420/256/2515 ; 692/53 ; 692/699/67/1504/1885 ; 692/700/478/174 ; Adult ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Biomedical and Life Sciences ; Biomedicine ; Blood & organ donations ; Body Mass Index ; C-Reactive Protein - analysis ; Cancer Research ; Colorectal cancer ; Colorectal Neoplasms - blood ; Cytokines ; Drug Resistance ; Epidemiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hospitals ; Human subjects ; Humans ; Inflammation ; Inflammation - blood ; Interleukin-6 - blood ; Laboratories ; Lifestyles ; Male ; Medical personnel ; Medical records ; Medical research ; Medical sciences ; Middle Aged ; Molecular Medicine ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Nonsteroidal anti-inflammatory drugs ; Oncology ; Plasma ; Prospective Studies ; Proteins ; Public health ; Questionnaires ; Receptors, Tumor Necrosis Factor, Type II - blood ; Risk ; Risk Assessment ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumor necrosis factor-TNF ; Tumors</subject><ispartof>British journal of cancer, 2013-05, Vol.108 (9), p.1891-1898</ispartof><rights>The Author(s) 2013</rights><rights>2014 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 14, 2013</rights><rights>Copyright © 2013 Cancer Research UK 2013 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-237c4bc3cbdfd8e9fd4b95242b6a0b1d763dcc5bdc44ebe7c6532657088480bf3</citedby><cites>FETCH-LOGICAL-c579t-237c4bc3cbdfd8e9fd4b95242b6a0b1d763dcc5bdc44ebe7c6532657088480bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658520/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658520/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27357992$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23591192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, M</creatorcontrib><creatorcontrib>Wu, K</creatorcontrib><creatorcontrib>Ogino, S</creatorcontrib><creatorcontrib>Fuchs, C S</creatorcontrib><creatorcontrib>Giovannucci, E L</creatorcontrib><creatorcontrib>Chan, A T</creatorcontrib><title>A prospective study of plasma inflammatory markers and risk of colorectal cancer in men</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent.
Methods:
We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study.
Results:
Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99–2.40;
P
trend
=0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78–2.05;
P
trend
=0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (
P
interaction
=0.03). We did not observe any significant association between CRP or sTNFR-2 and CRC.
Conclusion:
Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.</description><subject>692/420/256/2515</subject><subject>692/53</subject><subject>692/699/67/1504/1885</subject><subject>692/700/478/174</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood & organ donations</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - analysis</subject><subject>Cancer Research</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - blood</subject><subject>Cytokines</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hospitals</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Interleukin-6 - blood</subject><subject>Laboratories</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Medical personnel</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Oncology</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Public health</subject><subject>Questionnaires</subject><subject>Receptors, Tumor Necrosis Factor, Type II - blood</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1rFDEYh4NY7Fq9eZaACB6cNR-TSXIRSrG1UPCieAz5mjrbTDImM4X9781219qKB08h5Hl_7_vmAeAVRmuMqPhgNnZNEKZrzMkTsMKMkgYLwp-CFUKIN0gSdAyel7KpV4kEfwaOCWUSY0lW4PspnHIqk7fzcOthmRe3hamHU9Bl1HCIfdDjqOeUt3DU-cbnAnV0MA_lZsfZFFKuxTpAq6P1uZbA0ccX4KjXofiXh_MEfDv_9PXsc3P15eLy7PSqsYzLuSGU29ZYao3rnfCyd62RjLTEdBoZ7HhHnbXMONu23nhuu7pexzgSohXI9PQEfNznTosZvbM-zlkHNeWhTrtVSQ_q8UscfqjrdKtoxwQjqAa8OwTk9HPxZVbjUKwPQUeflqIwZZ2kWHL8PyghXDDEKvrmL3STlhzrT-woJDGvsZV6v6dsVVCy7-_nxkjt5KoqV-3kqiq34q8f7noP_7ZZgbcHQBerQ5-rkaH84WpTLu-4Zs-V-hSvfX4w3b8a_wKVhrxN</recordid><startdate>20130514</startdate><enddate>20130514</enddate><creator>Song, M</creator><creator>Wu, K</creator><creator>Ogino, S</creator><creator>Fuchs, C S</creator><creator>Giovannucci, E L</creator><creator>Chan, A T</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20130514</creationdate><title>A prospective study of plasma inflammatory markers and risk of colorectal cancer in men</title><author>Song, M ; Wu, K ; Ogino, S ; Fuchs, C S ; Giovannucci, E L ; Chan, A T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-237c4bc3cbdfd8e9fd4b95242b6a0b1d763dcc5bdc44ebe7c6532657088480bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>692/420/256/2515</topic><topic>692/53</topic><topic>692/699/67/1504/1885</topic><topic>692/700/478/174</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood & organ donations</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - analysis</topic><topic>Cancer Research</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - blood</topic><topic>Cytokines</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hospitals</topic><topic>Human subjects</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Interleukin-6 - blood</topic><topic>Laboratories</topic><topic>Lifestyles</topic><topic>Male</topic><topic>Medical personnel</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Oncology</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Public health</topic><topic>Questionnaires</topic><topic>Receptors, Tumor Necrosis Factor, Type II - blood</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, M</creatorcontrib><creatorcontrib>Wu, K</creatorcontrib><creatorcontrib>Ogino, S</creatorcontrib><creatorcontrib>Fuchs, C S</creatorcontrib><creatorcontrib>Giovannucci, E L</creatorcontrib><creatorcontrib>Chan, A T</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, M</au><au>Wu, K</au><au>Ogino, S</au><au>Fuchs, C S</au><au>Giovannucci, E L</au><au>Chan, A T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective study of plasma inflammatory markers and risk of colorectal cancer in men</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2013-05-14</date><risdate>2013</risdate><volume>108</volume><issue>9</issue><spage>1891</spage><epage>1898</epage><pages>1891-1898</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent.
Methods:
We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study.
Results:
Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99–2.40;
P
trend
=0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78–2.05;
P
trend
=0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (
P
interaction
=0.03). We did not observe any significant association between CRP or sTNFR-2 and CRC.
Conclusion:
Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23591192</pmid><doi>10.1038/bjc.2013.172</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2013-05, Vol.108 (9), p.1891-1898 |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 692/420/256/2515 692/53 692/699/67/1504/1885 692/700/478/174 Adult Aged Biological and medical sciences Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Blood & organ donations Body Mass Index C-Reactive Protein - analysis Cancer Research Colorectal cancer Colorectal Neoplasms - blood Cytokines Drug Resistance Epidemiology Gastroenterology. Liver. Pancreas. Abdomen Hospitals Human subjects Humans Inflammation Inflammation - blood Interleukin-6 - blood Laboratories Lifestyles Male Medical personnel Medical records Medical research Medical sciences Middle Aged Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nonsteroidal anti-inflammatory drugs Oncology Plasma Prospective Studies Proteins Public health Questionnaires Receptors, Tumor Necrosis Factor, Type II - blood Risk Risk Assessment Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor necrosis factor-TNF Tumors |
| title | A prospective study of plasma inflammatory markers and risk of colorectal cancer in men |
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