FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA

N 6 -methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N 6 -hydroxymethyladenosine (hm 6 A) and N 6 -formyladenosine (f 6 A), in mammalian messenger RNA. We show...

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Veröffentlicht in:	Nature communications 2013-01, Vol.4 (1), p.1798-1798, Article 1798
Hauptverfasser:	Fu, Ye, Jia, Guifang, Pang, Xueqin, Wang, Richard N., Wang, Xiao, Li, Charles J., Smemo, Scott, Dai, Qing, Bailey, Kathleen A., Nobrega, Marcelo A., Han, Ke-Li, Cui, Qiang, He, Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1645/2570 631/92/500 Adenosine - analogs & derivatives Adenosine - chemistry Adenosine - metabolism Alpha-Ketoglutarate-Dependent Dioxygenase FTO Animals Humanities and Social Sciences Humans Kinetics Mammals - metabolism Methylation Mice Models, Biological Molecular Dynamics Simulation multidisciplinary Oxidation-Reduction Protein Binding Proteins - metabolism RNA - chemistry RNA - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Science Science (multidisciplinary) Substrate Specificity
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