A Coupling of Benzamides and Donor/Acceptor Diazo Compounds To Form γ‑Lactams via Rh(III)-Catalyzed C–H Activation

The coupling of O-pivaloyl benzhydroxamic acids with donor/acceptor diazo compounds provides isoindolones in high yield. The reaction tolerates a broad range of benzhydroxamic acids and diazo compounds, including substituted 2,2,2-trifluorodiazoethanes. Mechanistic experiments suggested that C–H act...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-04, Vol.135 (14), p.5364-5367
Hauptverfasser:	Hyster, Todd K, Ruhl, Kyle E, Rovis, Tomislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Azo Compounds - chemistry Benzamides - chemistry Catalysis Isoindoles - chemical synthesis Isoindoles - chemistry Lactams - chemical synthesis Lactams - chemistry Molecular Structure Organometallic Compounds - chemistry Rhodium - chemistry
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