Alcohol Inhibits Luteinizing Hormone-Releasing Hormone Release by Activating the Endocannabinoid System

We hypothesized that ethanol (EtOH) might act through the endocannabinoid system to inhibit luteinizing hormone-releasing hormone (LHRH) release. Therefore, we examined the mechanism by which EtOH and anandamide (AEA), an endogenous cannabinoid, inhibit LHRH release from incubated medial basal hypot...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-03, Vol.101 (9), p.3264-3268
Hauptverfasser:	Fernández-Solari, Javier, Scorticati, Camila, Mohn, Claudia, De Laurentiis, Andrea, Billi, Silvia, Franchi, Ana, McCann, Samuel M., Rettori, Valeria
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Amino acids anandamide Anatomy & physiology Animals Arachidonic Acids - pharmacology Bicuculline - pharmacology Biological Sciences Cannabinoid Receptor Modulators - secretion Cannabinoid receptors Colforsin - pharmacology Cyclic AMP - metabolism Endocannabinoids Ethanol Ethanol - pharmacology GABA antagonists Gonadotropin-Releasing Hormone - blood Gonadotropin-Releasing Hormone - secretion Hormones Hypothalamus Hypothalamus, Middle - drug effects Hypothalamus, Middle - secretion Hypotheses Kinetics Luteinization Male N-Methylaspartate - pharmacology Naltrexone - pharmacology Neurons Neurotransmitters Polyunsaturated Alkamides Radioimmunoassay Rats Rats, Wistar Receptors
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