Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob disease

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are mammalian neurodegenerative disorders characterized by a posttranslational conversion and brain accumulation of an insoluble, protease-resistant isoform ( PrPSc) of the host-encoded cellular prion protein ( PrPC). Human and ani...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-03, Vol.101 (9), p.3065-3070
Hauptverfasser:	Casalone,C, Zanusso, G, Acutis, P, Ferrari, S, Capucci, L, Tagliavini, F, Monaco, S, Caramelli, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloids Animals Biochemistry Biological Sciences Brain - pathology Brain stem Cattle Codons Creutzfeldt Jakob syndrome Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - classification Creutzfeldt-Jakob Syndrome - etiology Creutzfeldt-Jakob Syndrome - pathology Encephalopathy, Bovine Spongiform - classification Encephalopathy, Bovine Spongiform - etiology Encephalopathy, Bovine Spongiform - pathology Humans Molecules Mutation Pathology Prion diseases Prions - genetics Protein Isoforms - isolation & purification PrPSc Proteins - isolation & purification Science Species Specificity Spongiform encephalopathies Thalamus Ungulates Zoonoses
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