Early-life and contemporaneous nutritional and environmental predictors of antibody response to vaccination in young Gambian adults

Highlights ► We investigate predictors of response to vaccination in young Gambian adults. ► We focus on both early-life and contemporary nutritional and environmental exposures. ► Pre-vaccination antibody titres were a consistent predictor of response to vaccination. ► No other consistent associati...

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Veröffentlicht in:	Vaccine 2012-07, Vol.30 (32), p.4842-4848
Hauptverfasser:	Moore, Sophie E, Richards, Anna A, Goldblatt, David, Ashton, Lindsey, Szu, Shousun Chen, Prentice, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adulthood adults Allergy and Immunology antibodies Antibodies, Bacterial - blood Antibody Formation Birth Weight blood serum Body Mass Index childhood Children & youth Female Gambia Humans Immune programming Immune system immunity infancy Infant Infant growth Laboratories Male neopterin Nutritional Status Pneumococcal Vaccines - administration & dosage Polysaccharides, Bacterial - administration & dosage Salmonella typhi Salmonella typhi - immunology Salmonella Vaccines - administration & dosage serotypes Vaccination Vaccine responses Vaccines Waist-Hip Ratio Young Adult
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Beschreibung
Zusammenfassung:	Highlights ► We investigate predictors of response to vaccination in young Gambian adults. ► We focus on both early-life and contemporary nutritional and environmental exposures. ► Pre-vaccination antibody titres were a consistent predictor of response to vaccination. ► No other consistent associations were observed.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.05.009