Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry

The dopaminergic neurons of the nigrostriatal dopamine (DA) projection from the substantia nigra to the dorsal striatum become dysfunctional and slowly degenerate in Parkinson’s disease, a neurodegenerative disorder that afflicts more than one million Americans. There is no specific known cause for...

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Veröffentlicht in:	ACS chemical neuroscience 2013-05, Vol.4 (5), p.782-789
Hauptverfasser:	Spanos, Marina, Gras-Najjar, Julie, Letchworth, Jeremy M, Sanford, Audrey L, Toups, J. Vincent, Sombers, Leslie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dopamine - metabolism Electric Stimulation Electrochemical Techniques Hydrogen Peroxide - metabolism Male Neostriatum - drug effects Neostriatum - metabolism Oxidative Stress Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Rotenone - pharmacology Uncoupling Agents - pharmacology
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