A human Dravet syndrome model from patient induced pluripotent stem cells

Dravet syndrome is a devastating infantile-onset epilepsy syndrome with cognitive deficits and autistic traits caused by genetic alterations in SCN1A gene encoding the α-subunit of the voltage-gated sodium channel Na(v)1.1. Disease modeling using patient-derived induced pluripotent stem cells (iPSCs...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular brain 2013-05, Vol.6 (1), p.19-19, Article 19
Hauptverfasser:	Higurashi, Norimichi, Uchida, Taku, Lossin, Christoph, Misumi, Yoshio, Okada, Yohei, Akamatsu, Wado, Imaizumi, Yoichi, Zhang, Bo, Nabeshima, Kazuki, Mori, Masayuki X, Katsurabayashi, Shutaro, Shirasaka, Yukiyoshi, Okano, Hideyuki, Hirose, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adult Age Analysis Autism Cell culture Cell Differentiation Cloning Computer software industry Defects Disease Drug therapy Epilepsies, Myoclonic - pathology Epilepsies, Myoclonic - physiopathology Epilepsy Female GABA Gene expression Genes, Reporter - genetics Grants Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Infant Lentivirus - metabolism Medicine Models, Biological Mutation NAV1.1 Voltage-Gated Sodium Channel - metabolism Neurons Neurons - metabolism Neurons - pathology Parvalbumins - genetics Parvalbumins - metabolism Pediatrics Proteins Real-Time Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Science Stem cell research Stem cells Technological change Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!