Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

Integrin‐linked kinase (ILK) is an adaptor protein required to establish and maintain the connection between integrins and the actin cytoskeleton. This linkage is essential for generating force between the extracellular matrix (ECM) and the cell during migration and matrix remodelling. The mechanism...

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Veröffentlicht in:	The EMBO journal 2013-05, Vol.32 (10), p.1409-1424
Hauptverfasser:	Radovanac, Korana, Morgner, Jessica, Schulz, Jan-Niklas, Blumbach, Katrin, Patterson, Cam, Geiger, Tamar, Mann, Matthias, Krieg, Thomas, Eckes, Beate, Fässler, Reinhard, Wickström, Sara A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Bleomycin - toxicity Cell adhesion & migration Cell Movement - physiology Cells, Cultured Cytoskeleton - metabolism Cytoskeleton - ultrastructure EMBO05 EMBO31 extracellular matrix Extracellular Matrix - metabolism Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology fibrosis Fibrosis - chemically induced Fibrosis - metabolism Focal Adhesions - physiology Gene expression Heat shock proteins Hsp90 HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism integrin integrin-linked kinase Kinases Mice Mice, Inbred C57BL Mice, Mutant Strains Molecular biology Proteasome Endopeptidase Complex - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Skin - drug effects Skin - pathology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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