Truncated p110 ERBB2 induces mammary epithelial cell migration, invasion and orthotopic xenograft formation, and is associated with loss of phosphorylated STAT5

Truncated-ERBB2 isoforms (t-ERBB2s), resulting from receptor proteolysis or alternative translation of the ERBB2 mRNA, exist in a subset of human breast tumors. t-ERBB2s lack the receptor extracellular domain targeted by therapeutic anti-ERBB2 antibodies and antibody–drug conjugates, including trast...

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Veröffentlicht in:	Oncogene 2013-05, Vol.32 (19), p.2463-2474
Hauptverfasser:	Ward, T M, Iorns, E, Liu, X, Hoe, N, Kim, P, Singh, S, Dean, S, Jegg, A-M, Gallas, M, Rodriguez, C, Lippman, M, Landgraf, R, Pegram, M D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/395 631/80/84/2336 692/420 Animals Apoptosis Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell adhesion & migration Cell Biology Cell Line, Tumor Cell migration Cell Movement - physiology Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Development and progression Female Gene expression Genetic aspects Human Genetics Humans Immunohistochemistry Internal Medicine Kinases Medicine Medicine & Public Health Mice Mice, Inbred NOD Mice, SCID Neoplasm Invasiveness Oncology Original original-article Peptide Fragments - metabolism Phosphorylation Physiological aspects Receptor, ErbB-2 - metabolism Risk factors Signal Transduction STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism Transplantation, Heterologous
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