A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation
Premature ejaculation is a sexual debilitating condition affecting a large number of men worldwide and leading to important dysfunctions influencing the patients’ affective and emotional life. Hyaluronic acid is a natural and safe compound that has been widely used not only in the aesthetic medicine...
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| Veröffentlicht in: | International journal of impotence research 2013-05, Vol.25 (3), p.117-120 |
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| creator | Littara, A Palmieri, B Rottigni, V Iannitti, T |
| description | Premature ejaculation is a sexual debilitating condition affecting a large number of men worldwide and leading to important dysfunctions influencing the patients’ affective and emotional life. Hyaluronic acid is a natural and safe compound that has been widely used not only in the aesthetic medicine clinic, but also for treatment of osteoarthritis. The present study shows the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation. A hundred and ten male patients were treated with hyaluronic acid injections in the deep dermis of their glans penis to increase the volume and the circumference of their penis to prevent male premature ejaculation and improve the patients’ and their partners’ sexual satisfaction. The intravaginal ejaculation latency time increased significantly from a baseline value of 88.34±3.14 s to 293.14±8.16 s after 6 months from the procedure. Maximal glandular circumference increased from 98.51±0.71 mm to 114.35±0.66 mm after 6 months from the procedure. At 6-month follow-up, patients’ self-rated satisfaction was 5.3±0.07 (range: 4–6). At the follow-up, partners’ self-rated satisfaction was 5.1±0.09 (range: 3–6). The present clinical study showed that hyaluronic acid injection is a promising treatment for premature ejaculation. The effect of the procedure in the long-term follow-up needs to be clarified. |
| doi_str_mv | 10.1038/ijir.2013.13 |
| format | Article |
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Hyaluronic acid is a natural and safe compound that has been widely used not only in the aesthetic medicine clinic, but also for treatment of osteoarthritis. The present study shows the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation. A hundred and ten male patients were treated with hyaluronic acid injections in the deep dermis of their glans penis to increase the volume and the circumference of their penis to prevent male premature ejaculation and improve the patients’ and their partners’ sexual satisfaction. The intravaginal ejaculation latency time increased significantly from a baseline value of 88.34±3.14 s to 293.14±8.16 s after 6 months from the procedure. Maximal glandular circumference increased from 98.51±0.71 mm to 114.35±0.66 mm after 6 months from the procedure. At 6-month follow-up, patients’ self-rated satisfaction was 5.3±0.07 (range: 4–6). At the follow-up, partners’ self-rated satisfaction was 5.1±0.09 (range: 3–6). The present clinical study showed that hyaluronic acid injection is a promising treatment for premature ejaculation. The effect of the procedure in the long-term follow-up needs to be clarified.</description><identifier>ISSN: 0955-9930</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/ijir.2013.13</identifier><identifier>PMID: 23552577</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/2732 ; 692/700/565 ; Adult ; Care and treatment ; Clinical trials ; Coitus ; Dermis - drug effects ; Humans ; Hyaluronic acid ; Hyaluronic Acid - administration & dosage ; Injections ; Male ; Medicine ; Medicine & Public Health ; Original ; original-article ; Osteoarthritis ; Patient Satisfaction ; Penis - drug effects ; Premature ejaculation ; Premature Ejaculation - drug therapy ; Reproductive Medicine ; rology ; Urology</subject><ispartof>International journal of impotence research, 2013-05, Vol.25 (3), p.117-120</ispartof><rights>The Author(s) 2013</rights><rights>COPYRIGHT 2013 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2013</rights><rights>Copyright © 2013 Macmillan Publishers Limited 2013 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-320a7ca15de0d17c351a8bda2b5cc7cbfe747e7bbad9e76f4390dd703784351d3</citedby><cites>FETCH-LOGICAL-c548t-320a7ca15de0d17c351a8bda2b5cc7cbfe747e7bbad9e76f4390dd703784351d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijir.2013.13$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijir.2013.13$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23552577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Littara, A</creatorcontrib><creatorcontrib>Palmieri, B</creatorcontrib><creatorcontrib>Rottigni, V</creatorcontrib><creatorcontrib>Iannitti, T</creatorcontrib><title>A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><addtitle>Int J Impot Res</addtitle><description>Premature ejaculation is a sexual debilitating condition affecting a large number of men worldwide and leading to important dysfunctions influencing the patients’ affective and emotional life. Hyaluronic acid is a natural and safe compound that has been widely used not only in the aesthetic medicine clinic, but also for treatment of osteoarthritis. The present study shows the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation. A hundred and ten male patients were treated with hyaluronic acid injections in the deep dermis of their glans penis to increase the volume and the circumference of their penis to prevent male premature ejaculation and improve the patients’ and their partners’ sexual satisfaction. The intravaginal ejaculation latency time increased significantly from a baseline value of 88.34±3.14 s to 293.14±8.16 s after 6 months from the procedure. Maximal glandular circumference increased from 98.51±0.71 mm to 114.35±0.66 mm after 6 months from the procedure. At 6-month follow-up, patients’ self-rated satisfaction was 5.3±0.07 (range: 4–6). At the follow-up, partners’ self-rated satisfaction was 5.1±0.09 (range: 3–6). The present clinical study showed that hyaluronic acid injection is a promising treatment for premature ejaculation. 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Palmieri, B ; Rottigni, V ; Iannitti, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-320a7ca15de0d17c351a8bda2b5cc7cbfe747e7bbad9e76f4390dd703784351d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>692/699/2732</topic><topic>692/700/565</topic><topic>Adult</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Coitus</topic><topic>Dermis - drug effects</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Injections</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>original-article</topic><topic>Osteoarthritis</topic><topic>Patient Satisfaction</topic><topic>Penis - drug effects</topic><topic>Premature ejaculation</topic><topic>Premature Ejaculation - drug therapy</topic><topic>Reproductive Medicine</topic><topic>rology</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Littara, A</creatorcontrib><creatorcontrib>Palmieri, B</creatorcontrib><creatorcontrib>Rottigni, V</creatorcontrib><creatorcontrib>Iannitti, T</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of impotence research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Littara, A</au><au>Palmieri, B</au><au>Rottigni, V</au><au>Iannitti, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation</atitle><jtitle>International journal of impotence research</jtitle><stitle>Int J Impot Res</stitle><addtitle>Int J Impot Res</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>25</volume><issue>3</issue><spage>117</spage><epage>120</epage><pages>117-120</pages><issn>0955-9930</issn><eissn>1476-5489</eissn><abstract>Premature ejaculation is a sexual debilitating condition affecting a large number of men worldwide and leading to important dysfunctions influencing the patients’ affective and emotional life. 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| ispartof | International journal of impotence research, 2013-05, Vol.25 (3), p.117-120 |
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| subjects | 692/699/2732 692/700/565 Adult Care and treatment Clinical trials Coitus Dermis - drug effects Humans Hyaluronic acid Hyaluronic Acid - administration & dosage Injections Male Medicine Medicine & Public Health Original original-article Osteoarthritis Patient Satisfaction Penis - drug effects Premature ejaculation Premature Ejaculation - drug therapy Reproductive Medicine rology Urology |
| title | A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation |
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