Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa

Background Solitary chemosensory cells (SCCs) are specialized cells in the respiratory epithelium that respond to noxious chemicals including bacterial signaling molecules. SCCs express components of bitter taste transduction including the taste receptor type 2 (TAS2R) bitter taste receptors and dow...

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Veröffentlicht in:	International forum of allergy & rhinology 2013-06, Vol.3 (6), p.450-457
Hauptverfasser:	Barham, Henry P., Cooper, Sarah E., Anderson, Catherine B., Tizzano, Marco, Kingdom, Todd T., Finger, Tom E., Kinnamon, Sue C., Ramakrishnan, Vijay R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged bitter taste transduction Case-Control Studies Chemoreceptor Cells - metabolism Chronic Disease Epithelium - metabolism Female Gene expression Humans inflammation Male Medical research Middle Aged Nasal Mucosa - metabolism Pain Phospholipase C beta - metabolism Polymerase Chain Reaction - methods Receptors, G-Protein-Coupled - metabolism respiratory epithelium rhinitis Rhinitis - metabolism Rhinitis, Allergic Rhinitis, Allergic, Perennial - metabolism rhinosinusitis Sinusitis - metabolism SNOT-22 solitary chemosensory cell Transducin - metabolism TRPM Cation Channels - metabolism
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