Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

The recent approval of Provenge has brought new hope for anticancer vaccine therapies. However, the immunosuppressive tumor microenvironment seems to impair the efficacy of vaccine therapies. The abnormal tumor vasculature creates a hypoxic microenvironment that polarizes inflammatory cells toward i...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-05, Vol.73 (10), p.2943-2948
Hauptverfasser:	YUHUI HUANG, GOEL, Shom, DUDA, Dan G, FUKUMURA, Dai, JAIN, Rakesh K
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - therapeutic use Animals Antineoplastic agents Biological and medical sciences Humans Immune Tolerance Immunotherapy Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - blood supply Neoplasms - immunology Neoplasms - therapy Pharmacology. Drug treatments T-Lymphocytes - immunology Tumor Microenvironment Tumors Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - physiology
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