Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

At therapeutic doses, acetaminophen (APAP) is a safe and effective analgesic. However, overdose of APAP is the principal cause of acute liver failure in the West. Binding of the reactive metabolite of APAP (NAPQI) to proteins is thought to be the initiating event in the mechanism of hepatotoxicity....

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-06, Vol.269 (3), p.240-249
Hauptverfasser:	McGill, Mitchell R., Lebofsky, Margitta, Norris, Hye-Ryun K., Slawson, Matthew H., Bajt, Mary Lynn, Xie, Yuchao, Williams, C. David, Wilkins, Diana G., Rollins, Douglas E., Jaeschke, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acetaminophen Acetaminophen - metabolism Acetaminophen - pharmacology ADDUCTS ANALGESICS Analgesics, Non-Narcotic - metabolism Analgesics, Non-Narcotic - pharmacology Animals Biological and medical sciences Cellular adduct release Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology CYSTEINE DISEASE INCIDENCE Dose-Response Relationship, Drug DOSES GLUTATHIONE Glutathione - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Hepatotoxicity IN VITRO INJURIES LIVER Liver - drug effects Liver - metabolism Male Medical sciences MICE Mice, Inbred C57BL NECROSIS Protein adducts Reperfusion Injury - metabolism SECRETION TOXICITY Toxicology
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