A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions

Eukaryotic transcription factors (TFs) perform complex and combinatorial functions within transcriptional networks. Here, we present a synthetic framework for systematically constructing eukaryotic transcription functions using artificial zinc fingers, modular DNA-binding domains found within many e...

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Veröffentlicht in:	Cell 2012-08, Vol.150 (3), p.647-658
Hauptverfasser:	Khalil, Ahmad S., Lu, Timothy K., Bashor, Caleb J., Ramirez, Cherie L., Pyenson, Nora C., Joung, J. Keith, Collins, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence complexing DNA Gene Regulatory Networks Models, Molecular Molecular Sequence Data protein-protein interactions Saccharomyces cerevisiae - genetics Synthetic Biology transcription (genetics) transcription factors Transcription Factors - metabolism Transcription, Genetic yeasts zinc finger motif Zinc Fingers
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