The Contribution of Parental Alcohol Use Disorders and Other Psychiatric Illness to the Risk of Alcohol Use Disorders in the Offspring
Background: Few population‐based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or wi...
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| Veröffentlicht in: | Alcoholism, clinical and experimental research clinical and experimental research, 2011-07, Vol.35 (7), p.1315-1320 |
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| creator | Sørensen, Holger J. Manzardo, Ann M. Knop, Joachim Penick, Elizabeth C. Madarasz, Wendy Nickel, Elizabeth J. Becker, Ulrik Mortensen, Erik L. |
| description | Background: Few population‐based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).
Methods: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.
Results: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.
Conclusions: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons. |
| doi_str_mv | 10.1111/j.1530-0277.2011.01467.x |
| format | Article |
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Methods: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.
Results: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.
Conclusions: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1111/j.1530-0277.2011.01467.x</identifier><identifier>PMID: 21676003</identifier><identifier>CODEN: ACRSDM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Addictive behaviors ; Adult and adolescent clinical studies ; Alcohol Abuse ; Alcohol use ; Alcohol Use Disorders ; Alcohol-Related Disorders - complications ; Alcohol-Related Disorders - epidemiology ; Alcohol-Related Disorders - psychology ; Alcoholism ; Alcoholism and acute alcohol poisoning ; Biological and medical sciences ; Child ; Child of Impaired Parents ; Cohort Studies ; Cohort Study ; Family History ; Female ; Gender ; Humans ; Illnesses ; Longitudinal Studies ; Male ; Medical sciences ; Mental Disorders - complications ; Mental Disorders - epidemiology ; Mental Disorders - psychology ; Parental Risk ; Parents - psychology ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Registries ; Risk Factors ; Sex Factors ; Studies ; Toxicology</subject><ispartof>Alcoholism, clinical and experimental research, 2011-07, Vol.35 (7), p.1315-1320</ispartof><rights>Copyright © 2011 by the Research Society on Alcoholism</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 by the Research Society on Alcoholism.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5917-7cc5f55ed6f7579423d1ef09dbf4de424cb78937ce30816cbd7181dab6fd0fc03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1530-0277.2011.01467.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1530-0277.2011.01467.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24321572$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21676003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sørensen, Holger J.</creatorcontrib><creatorcontrib>Manzardo, Ann M.</creatorcontrib><creatorcontrib>Knop, Joachim</creatorcontrib><creatorcontrib>Penick, Elizabeth C.</creatorcontrib><creatorcontrib>Madarasz, Wendy</creatorcontrib><creatorcontrib>Nickel, Elizabeth J.</creatorcontrib><creatorcontrib>Becker, Ulrik</creatorcontrib><creatorcontrib>Mortensen, Erik L.</creatorcontrib><title>The Contribution of Parental Alcohol Use Disorders and Other Psychiatric Illness to the Risk of Alcohol Use Disorders in the Offspring</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>Background: Few population‐based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).
Methods: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.
Results: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.
Conclusions: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.</description><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcohol Abuse</subject><subject>Alcohol use</subject><subject>Alcohol Use Disorders</subject><subject>Alcohol-Related Disorders - complications</subject><subject>Alcohol-Related Disorders - epidemiology</subject><subject>Alcohol-Related Disorders - psychology</subject><subject>Alcoholism</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child of Impaired Parents</subject><subject>Cohort Studies</subject><subject>Cohort Study</subject><subject>Family History</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Disorders - complications</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - psychology</subject><subject>Parental Risk</subject><subject>Parents - psychology</subject><subject>Prospective Studies</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Toxicology</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkt9u0zAUxi0EYmXwCsgS4jLBjv8lN0iljDGpotvY4NJyHHt1l9mbnUL7Ajw3zlY6kPCNrfN9_p1jnwMAxKjEeb1blZgRVKBKiLJCGJcIUy7KzRMw2QtPwSRHWcERqg_Ai5RWCCFac_4cHFSYixwnE_DrYmngLPghunY9uOBhsPBUReMH1cNpr8My9PAyGfjRpRA7ExNUvoOLYWkiPE1bvXQqX9bwpO-9SQkOAWYNnrt0PbL-j3D-3rSwNt1G569egmdW9cm82u2H4PLT0cXsczFfHJ_MpvNCswaLQmjNLGOm41Yw0dCKdNhY1HStpZ2hFdWtqBsitCGoxly3ncA17lTLbYesRuQQvH_g3q7bG9Pp_MyoeplruFFxK4Ny8l_Fu6W8Cj8k4YxQVGfAmx0ghru1SYNchXX0uWaJGaVCMF412fX67zR7_p9_z4a3O4NKWvU2Kq9devRRUmEmqsd6f7rebPc6RnKcA7mSY7vl2G45zoG8nwO5kdPZ0fl4zIDiAeDSYDZ7gIrXMquCye9fjmX1jc4_nH1l8oz8Bv71t2c</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Sørensen, Holger J.</creator><creator>Manzardo, Ann M.</creator><creator>Knop, Joachim</creator><creator>Penick, Elizabeth C.</creator><creator>Madarasz, Wendy</creator><creator>Nickel, Elizabeth J.</creator><creator>Becker, Ulrik</creator><creator>Mortensen, Erik L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>K7.</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>201107</creationdate><title>The Contribution of Parental Alcohol Use Disorders and Other Psychiatric Illness to the Risk of Alcohol Use Disorders in the Offspring</title><author>Sørensen, Holger J. ; Manzardo, Ann M. ; Knop, Joachim ; Penick, Elizabeth C. ; Madarasz, Wendy ; Nickel, Elizabeth J. ; Becker, Ulrik ; Mortensen, Erik L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5917-7cc5f55ed6f7579423d1ef09dbf4de424cb78937ce30816cbd7181dab6fd0fc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Addictive behaviors</topic><topic>Adult and adolescent clinical studies</topic><topic>Alcohol Abuse</topic><topic>Alcohol use</topic><topic>Alcohol Use Disorders</topic><topic>Alcohol-Related Disorders - complications</topic><topic>Alcohol-Related Disorders - epidemiology</topic><topic>Alcohol-Related Disorders - psychology</topic><topic>Alcoholism</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child of Impaired Parents</topic><topic>Cohort Studies</topic><topic>Cohort Study</topic><topic>Family History</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Disorders - complications</topic><topic>Mental Disorders - epidemiology</topic><topic>Mental Disorders - psychology</topic><topic>Parental Risk</topic><topic>Parents - psychology</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Studies</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sørensen, Holger J.</creatorcontrib><creatorcontrib>Manzardo, Ann M.</creatorcontrib><creatorcontrib>Knop, Joachim</creatorcontrib><creatorcontrib>Penick, Elizabeth C.</creatorcontrib><creatorcontrib>Madarasz, Wendy</creatorcontrib><creatorcontrib>Nickel, Elizabeth J.</creatorcontrib><creatorcontrib>Becker, Ulrik</creatorcontrib><creatorcontrib>Mortensen, Erik L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sørensen, Holger J.</au><au>Manzardo, Ann M.</au><au>Knop, Joachim</au><au>Penick, Elizabeth C.</au><au>Madarasz, Wendy</au><au>Nickel, Elizabeth J.</au><au>Becker, Ulrik</au><au>Mortensen, Erik L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Contribution of Parental Alcohol Use Disorders and Other Psychiatric Illness to the Risk of Alcohol Use Disorders in the Offspring</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2011-07</date><risdate>2011</risdate><volume>35</volume><issue>7</issue><spage>1315</spage><epage>1320</epage><pages>1315-1320</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><coden>ACRSDM</coden><abstract>Background: Few population‐based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).
Methods: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.
Results: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.
Conclusions: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21676003</pmid><doi>10.1111/j.1530-0277.2011.01467.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Addictive behaviors Adult and adolescent clinical studies Alcohol Abuse Alcohol use Alcohol Use Disorders Alcohol-Related Disorders - complications Alcohol-Related Disorders - epidemiology Alcohol-Related Disorders - psychology Alcoholism Alcoholism and acute alcohol poisoning Biological and medical sciences Child Child of Impaired Parents Cohort Studies Cohort Study Family History Female Gender Humans Illnesses Longitudinal Studies Male Medical sciences Mental Disorders - complications Mental Disorders - epidemiology Mental Disorders - psychology Parental Risk Parents - psychology Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Registries Risk Factors Sex Factors Studies Toxicology |
| title | The Contribution of Parental Alcohol Use Disorders and Other Psychiatric Illness to the Risk of Alcohol Use Disorders in the Offspring |
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