Lumican Regulates Ventilation-Induced Epithelial-Mesenchymal Transition Through Extracelluar Signal-Regulated Kinase Pathway

Background Mechanical ventilation used in patients with acute lung injury can damage pulmonary epithelial cells through production of inflammatory cytokines and excess deposition of the extracellular matrix protein lumican. Lumican participates in macrophage inflammatory protein (MIP)-2 and transfor...

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Veröffentlicht in:	Chest 2013-05, Vol.143 (5), p.1252-1260
Hauptverfasser:	Li, Li-Fu, MD, Chu, Pao-Hsien, MD, FCCP, Hung, Cheng-Yiu, MD, Kao, Winston W.-Y., MD, Lin, Meng-Chih, MD, Liu, Yung-Yang, MD, Yang, Cheng-Ta, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cadherins - physiology Chemokine CXCL2 - physiology Chondroitin Sulfate Proteoglycans - deficiency Chondroitin Sulfate Proteoglycans - physiology Disease Models, Animal Epithelial-Mesenchymal Transition - physiology Flavonoids - pharmacology Keratan Sulfate - deficiency Keratan Sulfate - physiology Lumican Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mice, Inbred C57BL Mice, Knockout Original Research Protein Kinase Inhibitors - pharmacology Pulmonary/Respiratory Respiration, Artificial - adverse effects Tidal Volume - physiology Transforming Growth Factor beta1 - physiology Ventilator-Induced Lung Injury - etiology Ventilator-Induced Lung Injury - physiopathology
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