Regulation of Microglial Phagocytosis and Inflammatory Gene Expression by Gas6 Acting on the Axl/Mer Family of Tyrosine Kinases

Removal of apoptotic cells is an essential process for normal development and tissue maintenance. Importantly, apoptotic cells stimulate their phagocytosis by macrophages while actively suppressing inflammatory responses. Growth arrest specific gene 6 (Gas6) is involved in this process, bridging pho...

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Veröffentlicht in:	Journal of neuroimmune pharmacology 2008-06, Vol.3 (2), p.130-140
Hauptverfasser:	Grommes, Christian, Lee, C. Y. Daniel, Wilkinson, Brandy L., Jiang, Qingguang, Koenigsknecht-Talboo, Jessica L., Varnum, Brian, Landreth, Gary E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Biomedical and Life Sciences Biomedicine Brain - metabolism c-Mer Tyrosine Kinase Cell Biology Cell Line - drug effects Cell Line - enzymology Cell Line - physiology Cytoskeleton - physiology Cytoskeleton - ultrastructure Gene expression Gene Expression Regulation - drug effects Immunology Inflammation - genetics Intercellular Signaling Peptides and Proteins - pharmacology Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - biosynthesis Interleukin-1beta - genetics Kinases Lipopolysaccharides - toxicity Mice Microglia - drug effects Microglia - enzymology Microglia - physiology Neurosciences Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics Oncogene Proteins - physiology Original Article Phagocytosis - drug effects Phagocytosis - physiology Pharmacology/Toxicology Phosphorylation Protein Processing, Post-Translational Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-vav - metabolism rac GTP-Binding Proteins - metabolism Receptor Protein-Tyrosine Kinases - physiology Recombinant Fusion Proteins - biosynthesis Transcription, Genetic - drug effects Virology
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