Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys
Background: The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedu...
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| Veröffentlicht in: | The American journal of clinical nutrition 2013-06, Vol.97 (6), p.1235-1242 |
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| creator | Cashman, Kevin D Kiely, Mairead Kinsella, Michael Durazo-Arvizu, Ramón A Tian, Lu Zhang, Yue Lucey, Alice Flynn, Albert Gibney, Michael J Vesper, Hubert W Phinney, Karen W Coates, Paul M Picciano, Mary F Sempos, Christopher T |
| description | Background: The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice.Objective: We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography–tandem mass spectrometry (LC–tandem MS).Design: The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.Results: Year-round prevalence rates for serum 25(OH)D concentrations |
| doi_str_mv | 10.3945/ajcn.112.057182 |
| format | Article |
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A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.Results: Year-round prevalence rates for serum 25(OH)D concentrations <30, <40, and <50 nmol/L were 6.5%, 21.9%, and 40.0%, respectively, via original ELISA measurements and 11.4%, 25.3%, and 43.7%, respectively, when VDSP protocols were applied. Differences in estimates at <30- and <40-nmol/L thresholds, but not at the <50-nmol/L threshold, were significant (P < 0.05). A reanalysis of all serums by using LC–tandem MS confirmed prevalence estimates as 11.2%, 27.2%, and 45.0%, respectively. Prevalences of serum 25(OH)D concentrations >125 nmol/L were 1.2%, 0.3%, and 0.6% by means of ELISA, VDSP protocols, and LC–tandem MS, respectively.Conclusion: VDSP protocols hold a major potential for national nutrition and health surveys in terms of the standardization of serum 25(OH)D data.]]></description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.112.057182</identifier><identifier>PMID: 23615829</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adolescent ; Adult ; adults ; Aged ; Aged, 80 and over ; Biological and medical sciences ; blood serum ; case studies ; Chromatography ; Chromatography, Liquid - methods ; clinical nutrition ; dietary surveys ; Enzyme-Linked Immunosorbent Assay ; equations ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Guidelines as Topic ; Humans ; Linear Models ; liquid chromatography ; Mass spectrometry ; Middle Aged ; Nutrition ; Nutrition Surveys ; Nutritional Status ; Public health ; Reference Standards ; Regression analysis ; Seasons ; tandem mass spectrometry ; Tandem Mass Spectrometry - methods ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - blood ; Vitamin D - standards ; Vitamin D Deficiency - prevention & control ; Vitamins, Minerals, and Phytochemicals ; Young Adult</subject><ispartof>The American journal of clinical nutrition, 2013-06, Vol.97 (6), p.1235-1242</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jun 1, 2013</rights><rights>2013 American Society for Nutrition 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-b5a34156e35ef41574a7df281bd2e80420103eaa3b55f52f78add90b0ffc1f123</citedby><cites>FETCH-LOGICAL-c508t-b5a34156e35ef41574a7df281bd2e80420103eaa3b55f52f78add90b0ffc1f123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27374682$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23615829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cashman, Kevin D</creatorcontrib><creatorcontrib>Kiely, Mairead</creatorcontrib><creatorcontrib>Kinsella, Michael</creatorcontrib><creatorcontrib>Durazo-Arvizu, Ramón A</creatorcontrib><creatorcontrib>Tian, Lu</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Lucey, Alice</creatorcontrib><creatorcontrib>Flynn, Albert</creatorcontrib><creatorcontrib>Gibney, Michael J</creatorcontrib><creatorcontrib>Vesper, Hubert W</creatorcontrib><creatorcontrib>Phinney, Karen W</creatorcontrib><creatorcontrib>Coates, Paul M</creatorcontrib><creatorcontrib>Picciano, Mary F</creatorcontrib><creatorcontrib>Sempos, Christopher T</creatorcontrib><title>Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description><![CDATA[Background: The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice.Objective: We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography–tandem mass spectrometry (LC–tandem MS).Design: The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.Results: Year-round prevalence rates for serum 25(OH)D concentrations <30, <40, and <50 nmol/L were 6.5%, 21.9%, and 40.0%, respectively, via original ELISA measurements and 11.4%, 25.3%, and 43.7%, respectively, when VDSP protocols were applied. Differences in estimates at <30- and <40-nmol/L thresholds, but not at the <50-nmol/L threshold, were significant (P < 0.05). A reanalysis of all serums by using LC–tandem MS confirmed prevalence estimates as 11.2%, 27.2%, and 45.0%, respectively. Prevalences of serum 25(OH)D concentrations >125 nmol/L were 1.2%, 0.3%, and 0.6% by means of ELISA, VDSP protocols, and LC–tandem MS, respectively.Conclusion: VDSP protocols hold a major potential for national nutrition and health surveys in terms of the standardization of serum 25(OH)D data.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>case studies</subject><subject>Chromatography</subject><subject>Chromatography, Liquid - methods</subject><subject>clinical nutrition</subject><subject>dietary surveys</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>equations</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guidelines as Topic</subject><subject>Humans</subject><subject>Linear Models</subject><subject>liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Nutritional Status</subject><subject>Public health</subject><subject>Reference Standards</subject><subject>Regression analysis</subject><subject>Seasons</subject><subject>tandem mass spectrometry</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - standards</subject><subject>Vitamin D Deficiency - prevention & control</subject><subject>Vitamins, Minerals, and Phytochemicals</subject><subject>Young Adult</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuO0zAUhiMEYjoDa3ZgCY1gk44vceKwQELDcJFGAmkYttZpYreuErtjOxXl3Xg3nKaUy4aFZVvnO_-56M-yJwTPWV3wC1g3dk4InWNeEUHvZTNSM5Eziqv72QxjTPOalPwkOw1hjTGhhSgfZieUlYQLWs-yH1db6AaIxlnkNPpqIvTGorfoJoJtwbfm-xT87N3SQ4823kXXuC4g7TwKR8rYJQrKDz2iPF_tWu--7bZHtRYivEKAGggqJQ3tbqwWV2rUG3VfBLRxUdlooNsr233Z9LFD9GbfQiqFVgq6uEJh8Fu1C4-yBxq6oB4f7rPs9t3Vl8sP-fWn9x8v31znDcci5gsOrCC8VIwrnR5VAVWrqSCLliqBC4oJZgqALTjXnOpKQNvWeIG1bogmlJ1lryfdzbDoVdukPj10cuNND34nHRj5d8SalVy6rWQlpzUdBV4eBLy7G1SIsjehUV0HVrkhSFJWgvO6xPz_KOOsFkxUIqHP_0HXbvBpaXuqxGlSxhJ1MVGNdyF4pY99EyxHF8nRRTK5SE4uShlP_xz3yP-yTQLODwCEBjrtwTYm_OYqVhXlXujZxGlwEpY-Mbc3adscj6fCBfsJpDTeMQ</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Cashman, Kevin D</creator><creator>Kiely, Mairead</creator><creator>Kinsella, Michael</creator><creator>Durazo-Arvizu, Ramón A</creator><creator>Tian, Lu</creator><creator>Zhang, Yue</creator><creator>Lucey, Alice</creator><creator>Flynn, Albert</creator><creator>Gibney, Michael J</creator><creator>Vesper, Hubert W</creator><creator>Phinney, Karen W</creator><creator>Coates, Paul M</creator><creator>Picciano, Mary F</creator><creator>Sempos, Christopher T</creator><general>American Society for Clinical Nutrition</general><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20130601</creationdate><title>Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys</title><author>Cashman, Kevin D ; Kiely, Mairead ; Kinsella, Michael ; Durazo-Arvizu, Ramón A ; Tian, Lu ; Zhang, Yue ; Lucey, Alice ; Flynn, Albert ; Gibney, Michael J ; Vesper, Hubert W ; Phinney, Karen W ; Coates, Paul M ; Picciano, Mary F ; Sempos, Christopher T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-b5a34156e35ef41574a7df281bd2e80420103eaa3b55f52f78add90b0ffc1f123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>case studies</topic><topic>Chromatography</topic><topic>Chromatography, Liquid - methods</topic><topic>clinical nutrition</topic><topic>dietary surveys</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>equations</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guidelines as Topic</topic><topic>Humans</topic><topic>Linear Models</topic><topic>liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Nutrition Surveys</topic><topic>Nutritional Status</topic><topic>Public health</topic><topic>Reference Standards</topic><topic>Regression analysis</topic><topic>Seasons</topic><topic>tandem mass spectrometry</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - standards</topic><topic>Vitamin D Deficiency - prevention & control</topic><topic>Vitamins, Minerals, and Phytochemicals</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cashman, Kevin D</creatorcontrib><creatorcontrib>Kiely, Mairead</creatorcontrib><creatorcontrib>Kinsella, Michael</creatorcontrib><creatorcontrib>Durazo-Arvizu, Ramón A</creatorcontrib><creatorcontrib>Tian, Lu</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Lucey, Alice</creatorcontrib><creatorcontrib>Flynn, Albert</creatorcontrib><creatorcontrib>Gibney, Michael J</creatorcontrib><creatorcontrib>Vesper, Hubert W</creatorcontrib><creatorcontrib>Phinney, Karen W</creatorcontrib><creatorcontrib>Coates, Paul M</creatorcontrib><creatorcontrib>Picciano, Mary F</creatorcontrib><creatorcontrib>Sempos, Christopher T</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cashman, Kevin D</au><au>Kiely, Mairead</au><au>Kinsella, Michael</au><au>Durazo-Arvizu, Ramón A</au><au>Tian, Lu</au><au>Zhang, Yue</au><au>Lucey, Alice</au><au>Flynn, Albert</au><au>Gibney, Michael J</au><au>Vesper, Hubert W</au><au>Phinney, Karen W</au><au>Coates, Paul M</au><au>Picciano, Mary F</au><au>Sempos, Christopher T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>97</volume><issue>6</issue><spage>1235</spage><epage>1242</epage><pages>1235-1242</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract><![CDATA[Background: The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice.Objective: We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography–tandem mass spectrometry (LC–tandem MS).Design: The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.Results: Year-round prevalence rates for serum 25(OH)D concentrations <30, <40, and <50 nmol/L were 6.5%, 21.9%, and 40.0%, respectively, via original ELISA measurements and 11.4%, 25.3%, and 43.7%, respectively, when VDSP protocols were applied. Differences in estimates at <30- and <40-nmol/L thresholds, but not at the <50-nmol/L threshold, were significant (P < 0.05). A reanalysis of all serums by using LC–tandem MS confirmed prevalence estimates as 11.2%, 27.2%, and 45.0%, respectively. Prevalences of serum 25(OH)D concentrations >125 nmol/L were 1.2%, 0.3%, and 0.6% by means of ELISA, VDSP protocols, and LC–tandem MS, respectively.Conclusion: VDSP protocols hold a major potential for national nutrition and health surveys in terms of the standardization of serum 25(OH)D data.]]></abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>23615829</pmid><doi>10.3945/ajcn.112.057182</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult adults Aged Aged, 80 and over Biological and medical sciences blood serum case studies Chromatography Chromatography, Liquid - methods clinical nutrition dietary surveys Enzyme-Linked Immunosorbent Assay equations Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Guidelines as Topic Humans Linear Models liquid chromatography Mass spectrometry Middle Aged Nutrition Nutrition Surveys Nutritional Status Public health Reference Standards Regression analysis Seasons tandem mass spectrometry Tandem Mass Spectrometry - methods Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - administration & dosage Vitamin D - blood Vitamin D - standards Vitamin D Deficiency - prevention & control Vitamins, Minerals, and Phytochemicals Young Adult |
| title | Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program's potential for national nutrition and health surveys |
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