Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program’s potential for national nutrition and health surveys12345
The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improv...
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| Veröffentlicht in: | The American journal of clinical nutrition 2013-06, Vol.97 (6), p.1235-1242 |
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| container_title | The American journal of clinical nutrition |
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| creator | Cashman, Kevin D Kiely, Mairead Kinsella, Michael Durazo-Arvizu, Ramón A Tian, Lu Zhang, Yue Lucey, Alice Flynn, Albert Gibney, Michael J Vesper, Hubert W Phinney, Karen W Coates, Paul M Picciano, Mary F Sempos, Christopher T |
| description | The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice.
We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography–tandem mass spectrometry (LC–tandem MS).
The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.
Year-round prevalence rates for serum 25(OH)D concentrations |
| doi_str_mv | 10.3945/ajcn.112.057182 |
| format | Article |
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We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography–tandem mass spectrometry (LC–tandem MS).
The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.
Year-round prevalence rates for serum 25(OH)D concentrations <30, <40, and <50 nmol/L were 6.5%, 21.9%, and 40.0%, respectively, via original ELISA measurements and 11.4%, 25.3%, and 43.7%, respectively, when VDSP protocols were applied. Differences in estimates at <30- and <40-nmol/L thresholds, but not at the <50-nmol/L threshold, were significant (P < 0.05). A reanalysis of all serums by using LC–tandem MS confirmed prevalence estimates as 11.2%, 27.2%, and 45.0%, respectively. Prevalences of serum 25(OH)D concentrations >125 nmol/L were 1.2%, 0.3%, and 0.6% by means of ELISA, VDSP protocols, and LC–tandem MS, respectively.
VDSP protocols hold a major potential for national nutrition and health surveys in terms of the standardization of serum 25(OH)D data.]]></description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.112.057182</identifier><identifier>PMID: 23615829</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Vitamins, Minerals, and Phytochemicals</subject><ispartof>The American journal of clinical nutrition, 2013-06, Vol.97 (6), p.1235-1242</ispartof><rights>2013 American Society for Nutrition.</rights><rights>2013 American Society for Nutrition 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Cashman, Kevin D</creatorcontrib><creatorcontrib>Kiely, Mairead</creatorcontrib><creatorcontrib>Kinsella, Michael</creatorcontrib><creatorcontrib>Durazo-Arvizu, Ramón A</creatorcontrib><creatorcontrib>Tian, Lu</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Lucey, Alice</creatorcontrib><creatorcontrib>Flynn, Albert</creatorcontrib><creatorcontrib>Gibney, Michael J</creatorcontrib><creatorcontrib>Vesper, Hubert W</creatorcontrib><creatorcontrib>Phinney, Karen W</creatorcontrib><creatorcontrib>Coates, Paul M</creatorcontrib><creatorcontrib>Picciano, Mary F</creatorcontrib><creatorcontrib>Sempos, Christopher T</creatorcontrib><title>Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program’s potential for national nutrition and health surveys12345</title><title>The American journal of clinical nutrition</title><description><![CDATA[The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice.
We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography–tandem mass spectrometry (LC–tandem MS).
The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.
Year-round prevalence rates for serum 25(OH)D concentrations <30, <40, and <50 nmol/L were 6.5%, 21.9%, and 40.0%, respectively, via original ELISA measurements and 11.4%, 25.3%, and 43.7%, respectively, when VDSP protocols were applied. Differences in estimates at <30- and <40-nmol/L thresholds, but not at the <50-nmol/L threshold, were significant (P < 0.05). A reanalysis of all serums by using LC–tandem MS confirmed prevalence estimates as 11.2%, 27.2%, and 45.0%, respectively. Prevalences of serum 25(OH)D concentrations >125 nmol/L were 1.2%, 0.3%, and 0.6% by means of ELISA, VDSP protocols, and LC–tandem MS, respectively.
VDSP protocols hold a major potential for national nutrition and health surveys in terms of the standardization of serum 25(OH)D data.]]></description><subject>Vitamins, Minerals, and Phytochemicals</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpVkU2O1DAQhS0EYpqBNVtfII1_2umEBRIahgFpJJD42VoVu9LxKLFbthMRVlyD-3CSOQlJNxqJVVWpqr73pEfIS862st6pV3Bn_JZzsWVqzyvxiGx4LatCCrZ_TDaMMVHUvFQX5FlKd4xxsavKp-RCyJKrStQb8ud6gn6E7IKnoaXfXYbBefqOfsngLUTrfp6Xn2M4RBjoMYYcTOgTbUOk6eHK-QNNGMeBClV0s43hxzw90CxkeE2BGki4PI12XtVyhytv5d7_-p3oMWT02UF_YvuT8DL4MUd3MrGI0Q6hzx1NY5xwTlzInXpOnrTQJ3zxr16Sb--vv159KG4_3Xy8entbIGdKFBU0vCxl1VQllowpY4RViluLrGn31kiGpqpbrAQoCTtgokFRNo1q6wqXXl6SN2fucWwGtGYxG6HXx-gGiLMO4PT_G-86fQiTlqUStRALoD4DcHE5OYw6GYfeoHURTdY2OM2ZXqPVa7R6iVafo5V_AWsTnrs</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Cashman, Kevin D</creator><creator>Kiely, Mairead</creator><creator>Kinsella, Michael</creator><creator>Durazo-Arvizu, Ramón A</creator><creator>Tian, Lu</creator><creator>Zhang, Yue</creator><creator>Lucey, Alice</creator><creator>Flynn, Albert</creator><creator>Gibney, Michael J</creator><creator>Vesper, Hubert W</creator><creator>Phinney, Karen W</creator><creator>Coates, Paul M</creator><creator>Picciano, Mary F</creator><creator>Sempos, Christopher T</creator><general>Elsevier Inc</general><general>American Society for Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>5PM</scope></search><sort><creationdate>201306</creationdate><title>Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program’s potential for national nutrition and health surveys12345</title><author>Cashman, Kevin D ; Kiely, Mairead ; Kinsella, Michael ; Durazo-Arvizu, Ramón A ; Tian, Lu ; Zhang, Yue ; Lucey, Alice ; Flynn, Albert ; Gibney, Michael J ; Vesper, Hubert W ; Phinney, Karen W ; Coates, Paul M ; Picciano, Mary F ; Sempos, Christopher T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1052-8ab16638b86e6005cc2d551dde0bf7dc30ec89fe82a53a4a02be26bb5f98e2be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Vitamins, Minerals, and Phytochemicals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cashman, Kevin D</creatorcontrib><creatorcontrib>Kiely, Mairead</creatorcontrib><creatorcontrib>Kinsella, Michael</creatorcontrib><creatorcontrib>Durazo-Arvizu, Ramón A</creatorcontrib><creatorcontrib>Tian, Lu</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Lucey, Alice</creatorcontrib><creatorcontrib>Flynn, Albert</creatorcontrib><creatorcontrib>Gibney, Michael J</creatorcontrib><creatorcontrib>Vesper, Hubert W</creatorcontrib><creatorcontrib>Phinney, Karen W</creatorcontrib><creatorcontrib>Coates, Paul M</creatorcontrib><creatorcontrib>Picciano, Mary F</creatorcontrib><creatorcontrib>Sempos, Christopher T</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cashman, Kevin D</au><au>Kiely, Mairead</au><au>Kinsella, Michael</au><au>Durazo-Arvizu, Ramón A</au><au>Tian, Lu</au><au>Zhang, Yue</au><au>Lucey, Alice</au><au>Flynn, Albert</au><au>Gibney, Michael J</au><au>Vesper, Hubert W</au><au>Phinney, Karen W</au><au>Coates, Paul M</au><au>Picciano, Mary F</au><au>Sempos, Christopher T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program’s potential for national nutrition and health surveys12345</atitle><jtitle>The American journal of clinical nutrition</jtitle><date>2013-06</date><risdate>2013</risdate><volume>97</volume><issue>6</issue><spage>1235</spage><epage>1242</epage><pages>1235-1242</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract><![CDATA[The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice.
We applied VDSP protocols to existing ELISA-derived serum 25(OH)D data from the Irish National Adult Nutrition Survey (NANS) as a case-study survey and evaluated their effectiveness by comparison of the protocol-projected estimates with those from a reanalysis of survey serums by using liquid chromatography–tandem mass spectrometry (LC–tandem MS).
The VDSP reference system and protocols were applied to ELISA-based serum 25(OH)D data from the representative NANS sample (n = 1118). A reanalysis of 99 stored serums by using standardized LC–tandem MS and resulting regression equations yielded predicted standardized serum 25(OH)D values, which were then compared with LC–tandem MS reanalyzed values for all serums.
Year-round prevalence rates for serum 25(OH)D concentrations <30, <40, and <50 nmol/L were 6.5%, 21.9%, and 40.0%, respectively, via original ELISA measurements and 11.4%, 25.3%, and 43.7%, respectively, when VDSP protocols were applied. Differences in estimates at <30- and <40-nmol/L thresholds, but not at the <50-nmol/L threshold, were significant (P < 0.05). A reanalysis of all serums by using LC–tandem MS confirmed prevalence estimates as 11.2%, 27.2%, and 45.0%, respectively. Prevalences of serum 25(OH)D concentrations >125 nmol/L were 1.2%, 0.3%, and 0.6% by means of ELISA, VDSP protocols, and LC–tandem MS, respectively.
VDSP protocols hold a major potential for national nutrition and health surveys in terms of the standardization of serum 25(OH)D data.]]></abstract><pub>Elsevier Inc</pub><pmid>23615829</pmid><doi>10.3945/ajcn.112.057182</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Vitamins, Minerals, and Phytochemicals |
| title | Evaluation of Vitamin D Standardization Program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program’s potential for national nutrition and health surveys12345 |
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