Adaptive Changes in the Neuronal Proteome: Mitochondrial Energy Production, Endoplasmic Reticulum Stress, and Ribosomal Dysfunction in the Cellular Response to Metabolic Stress

Impaired energy metabolism in neurons is integral to a range of neurodegenerative diseases, from Alzheimer's disease to stroke. To investigate the complex molecular changes underpinning cellular adaptation to metabolic stress, we have defined the proteomic response of the SH-SY5Y human neurobla...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2013-05, Vol.33 (5), p.673-683
Hauptverfasser:	Herrmann, Abigail G, Deighton, Ruth F, Bihan, Thierry Le, McCulloch, Mailis C, Searcy, James L, Kerr, Lorraine E, McCulloch, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Animals Cell Line, Tumor Cell Survival Endoplasmic Reticulum Stress Glucose - metabolism Humans Mitochondria - metabolism Mitochondria - pathology Mitochondrial Proteins - metabolism Neurons - metabolism Neurons - pathology Original Oxygen - metabolism Proteome - metabolism Ribosomal Proteins - metabolism Ribosomes - metabolism Ribosomes - pathology Stress, Physiological
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