NFKBIA Deletion in Glioblastomas

This study shows that the tumor-suppressor gene NFKBIA is deleted in glioblastomas and suggests a degree of mutual exclusivity between these deletions and amplification of EGFR in these tumors. Both NFKBIA deletion and EGFR amplification are associated with poor survival. Glioblastoma multiforme is...

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Veröffentlicht in:	The New England journal of medicine 2011-02, Vol.364 (7), p.627-637
Hauptverfasser:	Bredel, Claudia, Bredel, Markus, Scholtens, Denise M, Yadav, Ajay K, Alvarez, Angel A, Renfrow, Jaclyn J, Chandler, James P, Yu, Irene L.Y, Carro, Maria S, Dai, Fangping, Tagge, Michael J, Ferrarese, Roberto, Phillips, Heidi S, Lukac, Paul J, Robe, Pierre A, Weyerbrock, Astrid, Vogel, Hannes, Dubner, Steven, Mobley, Bret, He, Xiaolin, Scheck, Adrienne C, Sikic, Branimir I, Aldape, Kenneth D, Chakravarti, Arnab, Harsh, Griffith R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cancer DNA Mutational Analysis Gene Amplification Gene Deletion Gene Expression General aspects Genes Genes, erbB-1 Genetics & genetic processes Glioblastoma - genetics Glioblastoma - mortality Génétique & processus génétiques Humans I-kappa B Proteins - genetics Kaplan-Meier Estimate Life sciences Medical sciences Mutation Neurology NF-KappaB Inhibitor alpha Prognosis Proteins Sciences du vivant Tumor Cells, Cultured Tumors Tumors of the nervous system. Phacomatoses
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