In Vivo Animal Stroke Models: A Rationale for Rodent and Non-Human Primate Models
On average, every 4 min an individual dies from a stroke, accounting for one out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack Roger et al. (Circulation, 125(1): 188–197, 2012 ). T...
Gespeichert in:
| Veröffentlicht in: | Translational stroke research 2013-06, Vol.4 (3), p.308-321 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 321 |
|---|---|
| container_issue | 3 |
| container_start_page | 308 |
| container_title | Translational stroke research |
| container_volume | 4 |
| creator | Tajiri, Naoki Dailey, Travis Metcalf, Christopher Mosley, Yusef I. Lau, Tsz Staples, Meaghan van Loveren, Harry Kim, Seung U. Yamashima, Tetsumori Yasuhara, Takao Date, Isao Kaneko, Yuji Borlongan, Cesario V. |
| description | On average, every 4 min an individual dies from a stroke, accounting for one out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack Roger et al. (Circulation, 125(1): 188–197,
2012
). There have been multiple animal models of stroke demonstrating that novel therapeutics can help improve the clinical outcome. However, these results have failed to show the same outcomes when tested in human clinical trials. This review will discuss the current in vivo animal models of stroke, advantages and limitations, and the rationale for employing these animal models to satisfy translational gating items for examination of neuroprotective, as well as neurorestorative strategies in stroke patients. An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke. |
| doi_str_mv | 10.1007/s12975-012-0241-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3652482</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1467066115</sourcerecordid><originalsourceid>FETCH-LOGICAL-c351t-70cd711081c73b6b35549316db449b3a2891642d2c6f17b58b4e7e6241d3a3cf3</originalsourceid><addsrcrecordid>eNp9kM1LwzAchoMobsz9AYJIj16q-SVpkl6EMfwYTDz4gbfQpuns7JqZtAP_ezM6h17MJYHfmydvHoROAV8CxuLKA0lFEmMgMSYMYnKAhiC5jDmGt8PdmTFJB2js_RKHRYFxRo_RgFAuCUnTITqbNdFrtbHRpKlWWR09tc5-mOjBFqb2J-iozGpvxrt9hF5ub56n9_H88W42ncxjTRNoY4F1IQCwBC1oznOaJCylwIucsTSnGZEpcEYKonkJIk9kzowwPJQuaEZ1SUfouueuu3xlCm2a1mW1WrtQyX0pm1Xq76Sp3tXCbhTlCWGSBMDFDuDsZ2d8q1aV16aus8bYzqvwb4E5B0hCFPqodtZ7Z8r9M4DVVqzqxaogVm3Fqi3-_He__Y0fjSFA-oAPo2ZhnFrazjXB2T_Uby-rgPc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1467066115</pqid></control><display><type>article</type><title>In Vivo Animal Stroke Models: A Rationale for Rodent and Non-Human Primate Models</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>ProQuest Central</source><creator>Tajiri, Naoki ; Dailey, Travis ; Metcalf, Christopher ; Mosley, Yusef I. ; Lau, Tsz ; Staples, Meaghan ; van Loveren, Harry ; Kim, Seung U. ; Yamashima, Tetsumori ; Yasuhara, Takao ; Date, Isao ; Kaneko, Yuji ; Borlongan, Cesario V.</creator><creatorcontrib>Tajiri, Naoki ; Dailey, Travis ; Metcalf, Christopher ; Mosley, Yusef I. ; Lau, Tsz ; Staples, Meaghan ; van Loveren, Harry ; Kim, Seung U. ; Yamashima, Tetsumori ; Yasuhara, Takao ; Date, Isao ; Kaneko, Yuji ; Borlongan, Cesario V.</creatorcontrib><description>On average, every 4 min an individual dies from a stroke, accounting for one out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack Roger et al. (Circulation, 125(1): 188–197,
2012
). There have been multiple animal models of stroke demonstrating that novel therapeutics can help improve the clinical outcome. However, these results have failed to show the same outcomes when tested in human clinical trials. This review will discuss the current in vivo animal models of stroke, advantages and limitations, and the rationale for employing these animal models to satisfy translational gating items for examination of neuroprotective, as well as neurorestorative strategies in stroke patients. An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke.</description><identifier>ISSN: 1868-4483</identifier><identifier>EISSN: 1868-601X</identifier><identifier>DOI: 10.1007/s12975-012-0241-2</identifier><identifier>PMID: 23682299</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Aging - physiology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cardiology ; Cell Transplantation - methods ; Cell Transplantation - trends ; Diabetic Angiopathies - complications ; Disease Models, Animal ; Drug Combinations ; Heart Arrest - complications ; Hyperlipidemias - complications ; Hypertension - complications ; Neurology ; Neurosciences ; Neurosurgery ; Original Article ; Primates ; Rodentia ; Stem Cell Transplantation - methods ; Stem Cell Transplantation - trends ; Stroke - etiology ; Stroke - physiopathology ; Stroke - therapy ; Vascular Surgery</subject><ispartof>Translational stroke research, 2013-06, Vol.4 (3), p.308-321</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-70cd711081c73b6b35549316db449b3a2891642d2c6f17b58b4e7e6241d3a3cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12975-012-0241-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12975-012-0241-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,33722,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23682299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tajiri, Naoki</creatorcontrib><creatorcontrib>Dailey, Travis</creatorcontrib><creatorcontrib>Metcalf, Christopher</creatorcontrib><creatorcontrib>Mosley, Yusef I.</creatorcontrib><creatorcontrib>Lau, Tsz</creatorcontrib><creatorcontrib>Staples, Meaghan</creatorcontrib><creatorcontrib>van Loveren, Harry</creatorcontrib><creatorcontrib>Kim, Seung U.</creatorcontrib><creatorcontrib>Yamashima, Tetsumori</creatorcontrib><creatorcontrib>Yasuhara, Takao</creatorcontrib><creatorcontrib>Date, Isao</creatorcontrib><creatorcontrib>Kaneko, Yuji</creatorcontrib><creatorcontrib>Borlongan, Cesario V.</creatorcontrib><title>In Vivo Animal Stroke Models: A Rationale for Rodent and Non-Human Primate Models</title><title>Translational stroke research</title><addtitle>Transl. Stroke Res</addtitle><addtitle>Transl Stroke Res</addtitle><description>On average, every 4 min an individual dies from a stroke, accounting for one out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack Roger et al. (Circulation, 125(1): 188–197,
2012
). There have been multiple animal models of stroke demonstrating that novel therapeutics can help improve the clinical outcome. However, these results have failed to show the same outcomes when tested in human clinical trials. This review will discuss the current in vivo animal models of stroke, advantages and limitations, and the rationale for employing these animal models to satisfy translational gating items for examination of neuroprotective, as well as neurorestorative strategies in stroke patients. An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiology</subject><subject>Cell Transplantation - methods</subject><subject>Cell Transplantation - trends</subject><subject>Diabetic Angiopathies - complications</subject><subject>Disease Models, Animal</subject><subject>Drug Combinations</subject><subject>Heart Arrest - complications</subject><subject>Hyperlipidemias - complications</subject><subject>Hypertension - complications</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Primates</subject><subject>Rodentia</subject><subject>Stem Cell Transplantation - methods</subject><subject>Stem Cell Transplantation - trends</subject><subject>Stroke - etiology</subject><subject>Stroke - physiopathology</subject><subject>Stroke - therapy</subject><subject>Vascular Surgery</subject><issn>1868-4483</issn><issn>1868-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LwzAchoMobsz9AYJIj16q-SVpkl6EMfwYTDz4gbfQpuns7JqZtAP_ezM6h17MJYHfmydvHoROAV8CxuLKA0lFEmMgMSYMYnKAhiC5jDmGt8PdmTFJB2js_RKHRYFxRo_RgFAuCUnTITqbNdFrtbHRpKlWWR09tc5-mOjBFqb2J-iozGpvxrt9hF5ub56n9_H88W42ncxjTRNoY4F1IQCwBC1oznOaJCylwIucsTSnGZEpcEYKonkJIk9kzowwPJQuaEZ1SUfouueuu3xlCm2a1mW1WrtQyX0pm1Xq76Sp3tXCbhTlCWGSBMDFDuDsZ2d8q1aV16aus8bYzqvwb4E5B0hCFPqodtZ7Z8r9M4DVVqzqxaogVm3Fqi3-_He__Y0fjSFA-oAPo2ZhnFrazjXB2T_Uby-rgPc</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Tajiri, Naoki</creator><creator>Dailey, Travis</creator><creator>Metcalf, Christopher</creator><creator>Mosley, Yusef I.</creator><creator>Lau, Tsz</creator><creator>Staples, Meaghan</creator><creator>van Loveren, Harry</creator><creator>Kim, Seung U.</creator><creator>Yamashima, Tetsumori</creator><creator>Yasuhara, Takao</creator><creator>Date, Isao</creator><creator>Kaneko, Yuji</creator><creator>Borlongan, Cesario V.</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130601</creationdate><title>In Vivo Animal Stroke Models</title><author>Tajiri, Naoki ; Dailey, Travis ; Metcalf, Christopher ; Mosley, Yusef I. ; Lau, Tsz ; Staples, Meaghan ; van Loveren, Harry ; Kim, Seung U. ; Yamashima, Tetsumori ; Yasuhara, Takao ; Date, Isao ; Kaneko, Yuji ; Borlongan, Cesario V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-70cd711081c73b6b35549316db449b3a2891642d2c6f17b58b4e7e6241d3a3cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiology</topic><topic>Cell Transplantation - methods</topic><topic>Cell Transplantation - trends</topic><topic>Diabetic Angiopathies - complications</topic><topic>Disease Models, Animal</topic><topic>Drug Combinations</topic><topic>Heart Arrest - complications</topic><topic>Hyperlipidemias - complications</topic><topic>Hypertension - complications</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Primates</topic><topic>Rodentia</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem Cell Transplantation - trends</topic><topic>Stroke - etiology</topic><topic>Stroke - physiopathology</topic><topic>Stroke - therapy</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tajiri, Naoki</creatorcontrib><creatorcontrib>Dailey, Travis</creatorcontrib><creatorcontrib>Metcalf, Christopher</creatorcontrib><creatorcontrib>Mosley, Yusef I.</creatorcontrib><creatorcontrib>Lau, Tsz</creatorcontrib><creatorcontrib>Staples, Meaghan</creatorcontrib><creatorcontrib>van Loveren, Harry</creatorcontrib><creatorcontrib>Kim, Seung U.</creatorcontrib><creatorcontrib>Yamashima, Tetsumori</creatorcontrib><creatorcontrib>Yasuhara, Takao</creatorcontrib><creatorcontrib>Date, Isao</creatorcontrib><creatorcontrib>Kaneko, Yuji</creatorcontrib><creatorcontrib>Borlongan, Cesario V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational stroke research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tajiri, Naoki</au><au>Dailey, Travis</au><au>Metcalf, Christopher</au><au>Mosley, Yusef I.</au><au>Lau, Tsz</au><au>Staples, Meaghan</au><au>van Loveren, Harry</au><au>Kim, Seung U.</au><au>Yamashima, Tetsumori</au><au>Yasuhara, Takao</au><au>Date, Isao</au><au>Kaneko, Yuji</au><au>Borlongan, Cesario V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Animal Stroke Models: A Rationale for Rodent and Non-Human Primate Models</atitle><jtitle>Translational stroke research</jtitle><stitle>Transl. Stroke Res</stitle><addtitle>Transl Stroke Res</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>4</volume><issue>3</issue><spage>308</spage><epage>321</epage><pages>308-321</pages><issn>1868-4483</issn><eissn>1868-601X</eissn><abstract>On average, every 4 min an individual dies from a stroke, accounting for one out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack Roger et al. (Circulation, 125(1): 188–197,
2012
). There have been multiple animal models of stroke demonstrating that novel therapeutics can help improve the clinical outcome. However, these results have failed to show the same outcomes when tested in human clinical trials. This review will discuss the current in vivo animal models of stroke, advantages and limitations, and the rationale for employing these animal models to satisfy translational gating items for examination of neuroprotective, as well as neurorestorative strategies in stroke patients. An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23682299</pmid><doi>10.1007/s12975-012-0241-2</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1868-4483 |
| ispartof | Translational stroke research, 2013-06, Vol.4 (3), p.308-321 |
| issn | 1868-4483 1868-601X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3652482 |
| source | MEDLINE; SpringerLink Journals; ProQuest Central |
| subjects | Aging - physiology Animals Biomedical and Life Sciences Biomedicine Cardiology Cell Transplantation - methods Cell Transplantation - trends Diabetic Angiopathies - complications Disease Models, Animal Drug Combinations Heart Arrest - complications Hyperlipidemias - complications Hypertension - complications Neurology Neurosciences Neurosurgery Original Article Primates Rodentia Stem Cell Transplantation - methods Stem Cell Transplantation - trends Stroke - etiology Stroke - physiopathology Stroke - therapy Vascular Surgery |
| title | In Vivo Animal Stroke Models: A Rationale for Rodent and Non-Human Primate Models |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T01%3A44%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vivo%20Animal%20Stroke%20Models:%20A%20Rationale%20for%20Rodent%20and%20Non-Human%20Primate%20Models&rft.jtitle=Translational%20stroke%20research&rft.au=Tajiri,%20Naoki&rft.date=2013-06-01&rft.volume=4&rft.issue=3&rft.spage=308&rft.epage=321&rft.pages=308-321&rft.issn=1868-4483&rft.eissn=1868-601X&rft_id=info:doi/10.1007/s12975-012-0241-2&rft_dat=%3Cproquest_pubme%3E1467066115%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1467066115&rft_id=info:pmid/23682299&rfr_iscdi=true |