Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria

Thiol-group oxidation of active and allosteric cysteines is a widespread regulatory posttranslational protein modification. Pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus, use regulatory cysteine oxidation to respond to and overcome reactive oxygen species (ROS) enco...

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Veröffentlicht in:	Cell host & microbe 2013-03, Vol.13 (3), p.358-370
Hauptverfasser:	Deng, Xin, Weerapana, Eranthie, Ulanovskaya, Olesya, Sun, Fei, Liang, Haihua, Ji, Quanjiang, Ye, Yan, Fu, Ye, Zhou, Lu, Li, Jiaxin, Zhang, Haiyan, Wang, Chu, Alvarez, Sophie, Hicks, Leslie M., Lan, Lefu, Wu, Min, Cravatt, Benjamin F., He, Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Cysteine - metabolism Host-Pathogen Interactions Humans Hydrogen Peroxide Mice Mice, Inbred C57BL Oxidation-Reduction Oxidative Stress Proteome - genetics Proteome - metabolism Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - metabolism Pseudomonas Infections - metabolism Pseudomonas Infections - microbiology Reactive Oxygen Species - metabolism Staphylococcal Infections - metabolism Staphylococcal Infections - microbiology Staphylococcus aureus - genetics Staphylococcus aureus - metabolism
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