Activation of cannabinoid receptor 2 inhibits experimental cystitis

Cannabinoids have been shown to exert analgesic and anti-inflammatory effects, and the effects of cannabinoids are mediated primarily by cannabinoid receptors 1 and 2 (CB1and CB2). Both CB1 and CB2 are present in bladders of various species, including human, monkey, and rodents, and it appears that...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2013-05, Vol.304 (10), p.R846-R853
Hauptverfasser:	Wang, Zun-Yi, Wang, Peiqing, Bjorling, Dale E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein Animals Biochemistry Cannabinoid Receptor Agonists - pharmacology Cannabinoid Receptor Agonists - therapeutic use Cannabinoid Receptor Antagonists - pharmacology Cystitis - chemically induced Cystitis - drug therapy Cystitis - metabolism Dose-Response Relationship, Drug Female Gene expression Hyperalgesia - chemically induced Hyperalgesia - drug therapy Hyperalgesia - metabolism Indenes - pharmacology Indenes - therapeutic use Indoles - pharmacology Inflammatory diseases Kinases Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Pain Measurement Physical Activity and Inactivity Pyrazoles - pharmacology Pyrazoles - therapeutic use Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - metabolism Severity of Illness Index Urology
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