Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity

Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying physiologic and immunologic processes are not fully understood. The aim of this study was to determine whether TH9 cells develop in vivo in a model of chronic airway hyperreactivity (AHR) and what factors con...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-04, Vol.131 (4), p.1048-1057.e2
Hauptverfasser:	Kerzerho, Jerome, Maazi, Hadi, Speak, Anneliese O., Szely, Natacha, Lombardi, Vincent, Khoo, Bryant, Geryak, Stacey, Lam, Jonathan, Soroosh, Pejman, Van Snick, Jacques, Akbari, Omid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Allergens - immunology Allergies Animals Antibodies - immunology Aspergillus fumigatus Aspergillus fumigatus - immunology Asthma Biological and medical sciences Bronchial Hyperreactivity - genetics Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - pathology Cell death Cell Differentiation - immunology chronic airway hyperreactivity Chronic Disease Chronic obstructive pulmonary disease, asthma costimulation Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Immune system Immunopathology Interleukin-1alpha - immunology Interleukin-9 - immunology Lung - immunology Lung - metabolism Lung - pathology Lymphocyte Count Medical sciences Mice Mice, Inbred BALB C Mortality Pneumology Programmed Cell Death 1 Ligand 2 Protein - genetics Programmed Cell Death 1 Ligand 2 Protein - immunology programmed cell death ligand 2 Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology TGF-β TH9 Transforming Growth Factor beta - immunology
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