Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology

Summary Purpose: Dysfunction of the blood–brain barrier (BBB) is a common finding during seizures or following epileptogenic brain injuries, and experimentally induced BBB opening promotes seizures both in naive and epileptic animals. Brain albumin extravasation was reported to promote hyperexcitab...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Epilepsia (Copenhagen) 2012-11, Vol.53 (11), p.1887-1897
Hauptverfasser:	Frigerio, Federica, Frasca, Angelisa, Weissberg, Itai, Parrella, Sara, Friedman, Alon, Vezzani, Annamaria, Noe', Francesco M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Afterdischarge Albumin Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Astrocytes Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - physiopathology Brain - drug effects Brain - metabolism Brain - physiopathology Cerebellum Dextran EEG Electroencephalography - drug effects Electroencephalography - methods Epilepsy Extravasation Firing pattern Fluorescein isothiocyanate Forebrain Glial fibrillary acidic protein Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Immunohistochemistry Inflammation Injections, Intraventricular Male Medical sciences Nervous system (semeiology, syndromes) Neurodegeneration Neurology Neuropharmacology Pharmacology. Drug treatments Potassium channels (inwardly-rectifying) Proteoglycans Rats Rats, Sprague-Dawley Seizures Serum Albumin - metabolism Serum Albumin - toxicity Status Epilepticus - chemically induced Status Epilepticus - metabolism Status Epilepticus - physiopathology Time Factors Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!