Group A Streptococcal Cysteine Protease Cleaves Epithelial Junctions and Contributes to Bacterial Translocation

Group A Streptococcus (GAS) is an important human pathogen that possesses an ability to translocate across the epithelial barrier. In this study, culture supernatants of tested GAS strains showed proteolytic activity against human occludin and E-cadherin. Utilizing various types of protease inhibito...

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Veröffentlicht in:	The Journal of biological chemistry 2013-05, Vol.288 (19), p.13317-13324
Hauptverfasser:	Sumitomo, Tomoko, Nakata, Masanobu, Higashino, Miharu, Terao, Yutaka, Kawabata, Shigetada
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Bacterial Pathogenesis Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Translocation Caco-2 Cells Cadherins - chemistry Cadherins - metabolism Cell Polarity Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Cysteine Protease Electric Impedance Epithelial Cell Epithelial Cells - metabolism Epithelial Cells - microbiology Epithelium - microbiology Epithelium - pathology Exotoxins - genetics Exotoxins - metabolism Host-Pathogen Interactions Humans Intercellular Junctions - metabolism Intercellular Junctions - microbiology Junctions Microbiology Protein Structure, Tertiary Proteolysis Sequence Deletion Streptococcal Infections - microbiology Streptococcal Infections - pathology Streptococcus pyogenes - enzymology Streptococcus pyogenes - isolation & purification Streptococcus pyogenes - physiology
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