Numerical constraints and feedback control of double-strand breaks in mouse meiosis

Different organisms display widely different numbers of the programmed double-strand breaks (DSBs) that initiate meiotic recombination (e.g., hundreds per meiocyte in mice and humans vs. dozens in nematodes), but little is known about what drives these species-specific DSB set points or the regulato...

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Veröffentlicht in:	Genes & development 2013-04, Vol.27 (8), p.873-886
Hauptverfasser:	Kauppi, Liisa, Barchi, Marco, Lange, Julian, Baudat, Frédéric, Jasin, Maria, Keeney, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromosomes - genetics Chromosomes - metabolism DNA Breaks, Double-Stranded Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Feedback, Physiological Male Meiosis - genetics Mice Nematoda Research Paper Synaptonemal Complex - genetics Synaptonemal Complex - metabolism
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