Integrated nanopore sensing platform with sub-microsecond temporal resolution

The temporal resolution of current signals from solid-state nanopores is improved by integrating a complementary metal-oxide-semiconductor preamplifier with the nanopores in thin silicon nitride membranes. Nanopore sensors have attracted considerable interest for high-throughput sensing of individua...

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Veröffentlicht in:	Nature methods 2012-05, Vol.9 (5), p.487-492
Hauptverfasser:	Rosenstein, Jacob K, Wanunu, Meni, Merchant, Christopher A, Drndic, Marija, Shepard, Kenneth L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/350/1058 631/57/2265 Amplifiers, Electronic Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology CMOS Complementary metal oxide semiconductors Deoxyribonucleic acid DNA DNA - chemistry High-throughput screening (Biochemical assaying) Kinetics Life Sciences Methods Molecular biology Nanopores Nanotechnology Nanotechnology - instrumentation Nanotechnology - methods Nucleic acids Optics Properties Proteomics Sensors Signal transduction Signal-To-Noise Ratio Silicon
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