Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro

To investigate whether sequestosome 1/p62 （p62）, a key cargo adaptor protein involved in both the ubiquitin-proteasome system and the autophagy-lysosome system, could directly regulate autophagy in vitro. Methods： HEK 293 cells or HeLa cells were transfected with p62-expressing plasmids or siRNA tar...

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