Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS

Presently, there are no effective treatments for several diseases involving the CNS, which is protected by the blood–brain, blood–CSF, and blood–arachnoid barriers. Traversing any of these barriers is difficult, especially for macromolecular drugs and particulates. However, there is significant expe...

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Veröffentlicht in:	Molecular pharmaceutics 2013-05, Vol.10 (5), p.1522-1532
Hauptverfasser:	Papisov, Mikhail I, Belov, Vasily V, Gannon, Kimberley S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal Transport Biological Transport, Active Blood-Brain Barrier - physiology Brain - metabolism Central Nervous System Agents - administration & dosage Central Nervous System Agents - cerebrospinal fluid Central Nervous System Agents - pharmacokinetics Central Nervous System Diseases - cerebrospinal fluid Central Nervous System Diseases - drug therapy Central Nervous System Diseases - metabolism Drug Delivery Systems Humans Injections, Spinal Macromolecular Substances - administration & dosage Macromolecular Substances - cerebrospinal fluid Macromolecular Substances - pharmacokinetics Meninges - anatomy & histology Meninges - physiology Models, Animal
Online-Zugang:	Volltext
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