Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells

MiRNAs have been shown to be involved in regulation of multiple cellular processes including apoptosis. Since a single miRNA can affect the expression of several genes, the utilization of miRNAs for apoptosis engineering in mammalian cells can be more efficient than the conventional approach of mani...

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Veröffentlicht in:	Metabolic engineering 2013-03, Vol.16, p.87-94
Hauptverfasser:	Druz, Aliaksandr, Son, Young–Jin, Betenbaugh, Michael, Shiloach, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Animals Apoptosis Apoptosis - genetics Caspase 3 - biosynthesis Caspase 3 - genetics Caspase 7 - biosynthesis Caspase 7 - genetics cell culture Cell Survival - genetics cell viability CHO Cells Cricetinae Cricetulus engineering Gene Silencing genes Inhibitor of Apoptosis Proteins - biosynthesis Inhibitor of Apoptosis Proteins - genetics mammals MicroRNA MicroRNAs
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