A role for Piezo2 in EPAC1-dependent mechanical allodynia

Aberrant mechanosensation has an important role in different pain states. Here we show that Epac1 (cyclic AMP sensor) potentiation of Piezo2-mediated mechanotransduction contributes to mechanical allodynia. Dorsal root ganglia Epac1 mRNA levels increase during neuropathic pain, and nerve damage-indu...

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Veröffentlicht in:	Nature communications 2013-04, Vol.4 (1), p.1682, Article 1682
Hauptverfasser:	Eijkelkamp, N, Linley, J.E., Torres, J.M., Bee, L., Dickenson, A.H., Gringhuis, M., Minett, M.S., Hong, G.S., Lee, E., Oh, U., Ishikawa, Y., Zwartkuis, F.J., Cox, J.J., Wood, J.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2620/410 631/80/79/2066 Animals Base Sequence Cells, Cultured Guanine Nucleotide Exchange Factors - metabolism Guanine Nucleotide Exchange Factors - physiology Humanities and Social Sciences Hyperalgesia - etiology Ion Channels - physiology Mice Mice, Inbred C57BL Mice, Inbred CBA multidisciplinary Oligodeoxyribonucleotides Science Science (multidisciplinary) Signal Transduction
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