Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain

MeCP2 is a methyl-CpG-binding protein that is a main component of brain chromatin in vertebrates. In vitro studies have determined that in addition to its specific methyl-CpG-binding domain (MBD) MeCP2 also has several chromatin association domains. However, the specific interactions of MeCP2 with m...

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Veröffentlicht in:	Nucleic acids research 2013-05, Vol.41 (9), p.4888-4900
Hauptverfasser:	Stuss, David P, Cheema, Manjinder, Ng, Marlee K, Martinez de Paz, Alexia, Williamson, Brad, Missiaen, Kristal, Cosman, Joel D, McPhee, David, Esteller, Manel, Hendzel, Michael, Delaney, Kerry, Ausió, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	ADN Animals Brain - metabolism Cell Line, Tumor Cell Nucleus - chemistry Cell Nucleus - ultrastructure Chromatin Chromatin - metabolism Cromatina DNA Epigenetics Epigenètica Exons Gene Regulation, Chromatin and Epigenetics Genetic regulation Liver - metabolism Methyl-CpG-Binding Protein 2 - chemistry Methyl-CpG-Binding Protein 2 - genetics Methyl-CpG-Binding Protein 2 - metabolism Mice Mice, Transgenic Neurons - chemistry Neurons - ultrastructure Nucleosomes - metabolism Protein Structure, Tertiary Regulació genètica
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