The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

Defects in primary cilia result in human diseases known as ciliopathies. The retinitis pigmentosa GTPase regulator (RPGR), mutated in the most severe form of the eye disease, is located at the transition zone of the ciliary organelle. The RPGR‐interacting partner PDEδ is involved in trafficking of f...

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Veröffentlicht in:	EMBO reports 2013-05, Vol.14 (5), p.465-472
Hauptverfasser:	Wätzlich, Denise, Vetter, Ingrid, Gotthardt, Katja, Miertzschke, Mandy, Chen, Yong-Xiang, Wittinghofer, Alfred, Ismail, Shehab
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factors - chemistry Amino Acid Sequence Animals Arl2/Arl3 Binding Sites Cilia - physiology ciliary trafficking Conserved Sequence Crystallography, X-Ray Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry EMBO20 EMBO24 Eye Proteins - chemistry Eye Proteins - genetics GTP-Binding Proteins - chemistry Humans Lipid Metabolism Mice Models, Molecular Mutation, Missense PDEδ Protein Binding Protein Interaction Domains and Motifs Protein Prenylation Protein Structure, Quaternary Protein Structure, Secondary Protein Transport retinitis pigmentosa RPGR Scientific Report Scientific Reports
Online-Zugang:	Volltext
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