Agonist-induced Down-regulation of Endogenous Protein Kinase C α through an Endolysosomal Mechanism

Protein kinase C (PKC) isozymes undergo down-regulation upon sustained stimulation. Previous studies have pointed to the existence of both proteasome-dependent and -independent pathways of PKCα processing. Here we demonstrate that these down-regulation pathways are engaged in different subcellular c...

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Veröffentlicht in:	The Journal of biological chemistry 2013-05, Vol.288 (18), p.13093-13109
Hauptverfasser:	Lum, Michelle A., Pundt, Krista E., Paluch, Benjamin E., Black, Adrian R., Black, Jennifer D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caveolae Down-Regulation Endocytosis Endosomes - enzymology Endosomes - genetics Gene Expression Regulation, Enzymologic HeLa Cells Humans Lipid Raft Lysosomal Lysosomes Lysosomes - enzymology Lysosomes - genetics Membrane Microdomains - enzymology Membrane Microdomains - genetics Phosphorylation - genetics PKCα Degradation Protein Degradation Protein Kinase C (PKC) Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Protein Synthesis and Degradation Protein Transport Proteolysis rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Rats Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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