Association of dopamine-related genetic loci to dopamine D3 receptor antagonist ABT-925 clinical response

ABT-925, a selective dopamine D 3 receptor (DRD3) antagonist, was tested in schizophrenia. A DRD3 gene polymorphism results in an S9G amino-acid change that has been associated with lower risk of schizophrenia, higher affinity for dopamine and some antipsychotics, and differential response to some a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Translational psychiatry 2013-04, Vol.3 (4), p.e245-e245
Hauptverfasser:	Bhathena, A, Wang, Y, Kraft, J B, Idler, K B, Abel, S J, Holley-Shanks, R R, Robieson, W Z, Spear, B, Redden, L, Katz, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/436/434 692/699/476/1799 Adolescent Adult Aged Alleles Antipsychotic Agents - therapeutic use Behavioral Sciences Biological Psychology Catechol O-Methyltransferase - genetics Dopamine Antagonists - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Female Genotype Humans Male Medicine Medicine & Public Health Middle Aged Neurosciences Original original-article Pharmacotherapy Piperazines - therapeutic use Polymorphism, Single Nucleotide - genetics Psychiatric Status Rating Scales Psychiatry Pyrimidines - therapeutic use Receptors, Dopamine D3 - genetics Schizophrenia - drug therapy Schizophrenia - genetics Treatment Outcome Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!