Pathobiology and transmission of highly and low pathogenic avian influenza viruses in European quail (Coturnix c. coturnix)
European quail (Coturnix c. coturnix) may share with Japanese quail (Coturnix c. japonica) its potential as an intermediate host and reservoir of avian influenza viruses (AIV). To elucidate this question, European quail were experimentally challenged with two highly pathogenic AIV (HPAIV) (H7N1/HP a...
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| Veröffentlicht in: | Veterinary research (Paris) 2013-03, Vol.44 (1), p.23-23 |
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| creator | Bertran, Kateri Dolz, Roser Busquets, Núria Gamino, Virginia Vergara-Alert, Júlia Chaves, Aida J Ramis, Antonio Abad, F Xavier Höfle, Ursula Majó, Natàlia |
| description | European quail (Coturnix c. coturnix) may share with Japanese quail (Coturnix c. japonica) its potential as an intermediate host and reservoir of avian influenza viruses (AIV). To elucidate this question, European quail were experimentally challenged with two highly pathogenic AIV (HPAIV) (H7N1/HP and H5N1/HP) and one low pathogenic AIV (LPAIV) (H7N2/LP). Contact animals were also used to assess the viral transmission among birds. Severe neurological signs and mortality rates of 67% (H7N1/HP) and 92% (H5N1/HP) were observed. Although histopathological findings were present in both HPAIV-infected groups, H5N1/HP-quail displayed a broader viral antigen distribution and extent of microscopic lesions. Neither clinical nor pathological involvement was observed in LPAIV-infected quail. Consistent long-term viral shedding and effective transmission to naive quail was demonstrated for the three studied AIV. Drinking water arose as a possible transmission route and feathers as a potential origin of HPAIV dissemination. The present study demonstrates that European quail may play a major role in AI epidemiology, highlighting the need to further understand its putative role as an intermediate host for avian/mammalian reassortant viruses. |
| doi_str_mv | 10.1186/1297-9716-44-23 |
| format | Article |
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To elucidate this question, European quail were experimentally challenged with two highly pathogenic AIV (HPAIV) (H7N1/HP and H5N1/HP) and one low pathogenic AIV (LPAIV) (H7N2/LP). Contact animals were also used to assess the viral transmission among birds. Severe neurological signs and mortality rates of 67% (H7N1/HP) and 92% (H5N1/HP) were observed. Although histopathological findings were present in both HPAIV-infected groups, H5N1/HP-quail displayed a broader viral antigen distribution and extent of microscopic lesions. Neither clinical nor pathological involvement was observed in LPAIV-infected quail. Consistent long-term viral shedding and effective transmission to naive quail was demonstrated for the three studied AIV. Drinking water arose as a possible transmission route and feathers as a potential origin of HPAIV dissemination. The present study demonstrates that European quail may play a major role in AI epidemiology, highlighting the need to further understand its putative role as an intermediate host for avian/mammalian reassortant viruses.</description><identifier>ISSN: 1297-9716</identifier><identifier>ISSN: 0928-4249</identifier><identifier>EISSN: 1297-9716</identifier><identifier>DOI: 10.1186/1297-9716-44-23</identifier><identifier>PMID: 23537387</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Avian influenza ; Avian influenza viruses ; Coturnix ; Development and progression ; Disease transmission ; Enzyme-Linked Immunosorbent Assay - veterinary ; Epidemiology ; Female ; Influenza A Virus, H5N1 Subtype - pathogenicity ; Influenza A Virus, H5N1 Subtype - physiology ; Influenza A Virus, H7N1 Subtype - pathogenicity ; Influenza A Virus, H7N1 Subtype - physiology ; Influenza A Virus, H7N2 Subtype - pathogenicity ; Influenza A Virus, H7N2 Subtype - physiology ; Influenza in Birds - transmission ; Influenza in Birds - virology ; Male ; Polymerase Chain Reaction - veterinary ; Quails ; Random Allocation ; Viral antigens ; Virus Shedding</subject><ispartof>Veterinary research (Paris), 2013-03, Vol.44 (1), p.23-23</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>Copyright © 2013 Bertran et al.; licensee BioMed Central Ltd. 2013 Bertran et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b585t-1c77f3a146f150353bd709d302b1b55131adc40f17fc3bcbcf3b68d9484213093</citedby><cites>FETCH-LOGICAL-b585t-1c77f3a146f150353bd709d302b1b55131adc40f17fc3bcbcf3b68d9484213093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640924/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640924/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23537387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bertran, Kateri</creatorcontrib><creatorcontrib>Dolz, Roser</creatorcontrib><creatorcontrib>Busquets, Núria</creatorcontrib><creatorcontrib>Gamino, Virginia</creatorcontrib><creatorcontrib>Vergara-Alert, Júlia</creatorcontrib><creatorcontrib>Chaves, Aida J</creatorcontrib><creatorcontrib>Ramis, Antonio</creatorcontrib><creatorcontrib>Abad, F Xavier</creatorcontrib><creatorcontrib>Höfle, Ursula</creatorcontrib><creatorcontrib>Majó, Natàlia</creatorcontrib><title>Pathobiology and transmission of highly and low pathogenic avian influenza viruses in European quail (Coturnix c. coturnix)</title><title>Veterinary research (Paris)</title><addtitle>Vet Res</addtitle><description>European quail (Coturnix c. coturnix) may share with Japanese quail (Coturnix c. japonica) its potential as an intermediate host and reservoir of avian influenza viruses (AIV). To elucidate this question, European quail were experimentally challenged with two highly pathogenic AIV (HPAIV) (H7N1/HP and H5N1/HP) and one low pathogenic AIV (LPAIV) (H7N2/LP). Contact animals were also used to assess the viral transmission among birds. Severe neurological signs and mortality rates of 67% (H7N1/HP) and 92% (H5N1/HP) were observed. Although histopathological findings were present in both HPAIV-infected groups, H5N1/HP-quail displayed a broader viral antigen distribution and extent of microscopic lesions. Neither clinical nor pathological involvement was observed in LPAIV-infected quail. Consistent long-term viral shedding and effective transmission to naive quail was demonstrated for the three studied AIV. Drinking water arose as a possible transmission route and feathers as a potential origin of HPAIV dissemination. The present study demonstrates that European quail may play a major role in AI epidemiology, highlighting the need to further understand its putative role as an intermediate host for avian/mammalian reassortant viruses.</description><subject>Animals</subject><subject>Avian influenza</subject><subject>Avian influenza viruses</subject><subject>Coturnix</subject><subject>Development and progression</subject><subject>Disease transmission</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Influenza A Virus, H5N1 Subtype - pathogenicity</subject><subject>Influenza A Virus, H5N1 Subtype - physiology</subject><subject>Influenza A Virus, H7N1 Subtype - pathogenicity</subject><subject>Influenza A Virus, H7N1 Subtype - physiology</subject><subject>Influenza A Virus, H7N2 Subtype - pathogenicity</subject><subject>Influenza A Virus, H7N2 Subtype - physiology</subject><subject>Influenza in Birds - transmission</subject><subject>Influenza in Birds - virology</subject><subject>Male</subject><subject>Polymerase Chain Reaction - veterinary</subject><subject>Quails</subject><subject>Random Allocation</subject><subject>Viral antigens</subject><subject>Virus Shedding</subject><issn>1297-9716</issn><issn>0928-4249</issn><issn>1297-9716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kk1r3DAQhk1paT7ac29F0Ety8EayJMu-FNIl_YBAe2jPQpIlr4osbSR707R_vjLeLllI0UHDzDMvMy9TFG8QXCHU1FeoalnZMlSXhJQVflacHjLPH8UnxVlKPyFENabkZXFSYYoZbthp8eebGDdB2uBC_wCE78AYhU-DTckGD4IBG9tv3FJy4R5sZ77X3iogdlZ4YL1xk_a_BdjZOCWdcgbcTDFsda7eTcI6cLEO4xS9_QXUCqh9fPmqeGGES_r1_j8vfny8-b7-XN5-_fRlfX1bStrQsUSKMYMFIrVBFObJZcdg22FYSSQpRRiJThFoEDMKSyWVwbJuupY0pEIYtvi8eL_obic56E5pn3d0fBvtIOIDD8Ly44q3G96HHcc1gW1FssCHRSD79B-B44oKA5_N57P5nBBe4SxysZ8ihrtJp5Fnk5V2TngdpsQRJg2FuYtm9N2C9sJpng0OWVXNOL-mGUMtZDO1eoLKr9ODVcFrY3P-qOFqaVAxpBS1OWyAIJ_P6YmZ3z527sD_ux_8F5yjx0Y</recordid><startdate>20130328</startdate><enddate>20130328</enddate><creator>Bertran, Kateri</creator><creator>Dolz, Roser</creator><creator>Busquets, Núria</creator><creator>Gamino, Virginia</creator><creator>Vergara-Alert, Júlia</creator><creator>Chaves, Aida J</creator><creator>Ramis, Antonio</creator><creator>Abad, F Xavier</creator><creator>Höfle, Ursula</creator><creator>Majó, Natàlia</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130328</creationdate><title>Pathobiology and transmission of highly and low pathogenic avian influenza viruses in European quail (Coturnix c. coturnix)</title><author>Bertran, Kateri ; Dolz, Roser ; Busquets, Núria ; Gamino, Virginia ; Vergara-Alert, Júlia ; Chaves, Aida J ; Ramis, Antonio ; Abad, F Xavier ; Höfle, Ursula ; Majó, Natàlia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b585t-1c77f3a146f150353bd709d302b1b55131adc40f17fc3bcbcf3b68d9484213093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Avian influenza</topic><topic>Avian influenza viruses</topic><topic>Coturnix</topic><topic>Development and progression</topic><topic>Disease transmission</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Influenza A Virus, H5N1 Subtype - pathogenicity</topic><topic>Influenza A Virus, H5N1 Subtype - physiology</topic><topic>Influenza A Virus, H7N1 Subtype - pathogenicity</topic><topic>Influenza A Virus, H7N1 Subtype - physiology</topic><topic>Influenza A Virus, H7N2 Subtype - pathogenicity</topic><topic>Influenza A Virus, H7N2 Subtype - physiology</topic><topic>Influenza in Birds - transmission</topic><topic>Influenza in Birds - virology</topic><topic>Male</topic><topic>Polymerase Chain Reaction - veterinary</topic><topic>Quails</topic><topic>Random Allocation</topic><topic>Viral antigens</topic><topic>Virus Shedding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bertran, Kateri</creatorcontrib><creatorcontrib>Dolz, Roser</creatorcontrib><creatorcontrib>Busquets, Núria</creatorcontrib><creatorcontrib>Gamino, Virginia</creatorcontrib><creatorcontrib>Vergara-Alert, Júlia</creatorcontrib><creatorcontrib>Chaves, Aida J</creatorcontrib><creatorcontrib>Ramis, Antonio</creatorcontrib><creatorcontrib>Abad, F Xavier</creatorcontrib><creatorcontrib>Höfle, Ursula</creatorcontrib><creatorcontrib>Majó, Natàlia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Veterinary research (Paris)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertran, Kateri</au><au>Dolz, Roser</au><au>Busquets, Núria</au><au>Gamino, Virginia</au><au>Vergara-Alert, Júlia</au><au>Chaves, Aida J</au><au>Ramis, Antonio</au><au>Abad, F Xavier</au><au>Höfle, Ursula</au><au>Majó, Natàlia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathobiology and transmission of highly and low pathogenic avian influenza viruses in European quail (Coturnix c. coturnix)</atitle><jtitle>Veterinary research (Paris)</jtitle><addtitle>Vet Res</addtitle><date>2013-03-28</date><risdate>2013</risdate><volume>44</volume><issue>1</issue><spage>23</spage><epage>23</epage><pages>23-23</pages><issn>1297-9716</issn><issn>0928-4249</issn><eissn>1297-9716</eissn><abstract>European quail (Coturnix c. coturnix) may share with Japanese quail (Coturnix c. japonica) its potential as an intermediate host and reservoir of avian influenza viruses (AIV). To elucidate this question, European quail were experimentally challenged with two highly pathogenic AIV (HPAIV) (H7N1/HP and H5N1/HP) and one low pathogenic AIV (LPAIV) (H7N2/LP). Contact animals were also used to assess the viral transmission among birds. Severe neurological signs and mortality rates of 67% (H7N1/HP) and 92% (H5N1/HP) were observed. Although histopathological findings were present in both HPAIV-infected groups, H5N1/HP-quail displayed a broader viral antigen distribution and extent of microscopic lesions. Neither clinical nor pathological involvement was observed in LPAIV-infected quail. Consistent long-term viral shedding and effective transmission to naive quail was demonstrated for the three studied AIV. Drinking water arose as a possible transmission route and feathers as a potential origin of HPAIV dissemination. The present study demonstrates that European quail may play a major role in AI epidemiology, highlighting the need to further understand its putative role as an intermediate host for avian/mammalian reassortant viruses.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23537387</pmid><doi>10.1186/1297-9716-44-23</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerNature Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Avian influenza Avian influenza viruses Coturnix Development and progression Disease transmission Enzyme-Linked Immunosorbent Assay - veterinary Epidemiology Female Influenza A Virus, H5N1 Subtype - pathogenicity Influenza A Virus, H5N1 Subtype - physiology Influenza A Virus, H7N1 Subtype - pathogenicity Influenza A Virus, H7N1 Subtype - physiology Influenza A Virus, H7N2 Subtype - pathogenicity Influenza A Virus, H7N2 Subtype - physiology Influenza in Birds - transmission Influenza in Birds - virology Male Polymerase Chain Reaction - veterinary Quails Random Allocation Viral antigens Virus Shedding |
| title | Pathobiology and transmission of highly and low pathogenic avian influenza viruses in European quail (Coturnix c. coturnix) |
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