A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas
Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was to compare the proteomic profiles between adrenocortical carcinomas (ACC) and normal adrenocortical tissues in order to identify novel...
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| Veröffentlicht in: | Diagnostic pathology 2013-04, Vol.8 (1), p.58-58, Article 58 |
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| creator | Yang, Ming-shan Wang, Huan-sheng Wang, Bao-sheng Li, Wan-hu Pang, Zeng-fen Zou, Ben-kui Zhang, Xin Shi, Xue-tao Mu, Dian-bin Zhang, De-xian Gao, Yong-sheng Sun, Xiao-wen Xia, Shu-jie |
| description | Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was to compare the proteomic profiles between adrenocortical carcinomas (ACC) and normal adrenocortical tissues in order to identify novel potential biomarkers for ACC.
The protein samples from 12 ACC tissues and their paired adjacent normal adrenocortical tissues were profiled with two-dimensional electrophoresis; and differentially expressed proteins were identified by mass spectrometry. Expression patterns of three differently expressed proteins calreticulin, prohibitin and HSP60 in ACC, adrenocortical adenomas (ACA) and normal adrenocortical tissues were further validated by immunohistochemistry.
In our proteomic study, we identified 20 up-regulated and 9 down-regulated proteins in ACC tissues compared with paired normal controls. Most of the up-regulated proteins were focused in protein binding and oxidoreductase activity in Gene Ontology (GO) molecular function classification. By immunohistochemistry, two biomarkers calreticulin and prohibitin were validated to be overexpressed in ACC compared with adrenocortical adenomas (ACA) and normal tissues, but also calreticulin overexpression was significantly associated with tumor stages of ACC.
For the first time, calreticulin and prohibitin were identified to be novel candidate biomarkers for ACC, and their roles during ACC carcinogenesis and clinical significance deserves further investigation.
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1897372598927465. |
| doi_str_mv | 10.1186/1746-1596-8-58 |
| format | Article |
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The protein samples from 12 ACC tissues and their paired adjacent normal adrenocortical tissues were profiled with two-dimensional electrophoresis; and differentially expressed proteins were identified by mass spectrometry. Expression patterns of three differently expressed proteins calreticulin, prohibitin and HSP60 in ACC, adrenocortical adenomas (ACA) and normal adrenocortical tissues were further validated by immunohistochemistry.
In our proteomic study, we identified 20 up-regulated and 9 down-regulated proteins in ACC tissues compared with paired normal controls. Most of the up-regulated proteins were focused in protein binding and oxidoreductase activity in Gene Ontology (GO) molecular function classification. By immunohistochemistry, two biomarkers calreticulin and prohibitin were validated to be overexpressed in ACC compared with adrenocortical adenomas (ACA) and normal tissues, but also calreticulin overexpression was significantly associated with tumor stages of ACC.
For the first time, calreticulin and prohibitin were identified to be novel candidate biomarkers for ACC, and their roles during ACC carcinogenesis and clinical significance deserves further investigation.
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1897372598927465.</description><identifier>ISSN: 1746-1596</identifier><identifier>EISSN: 1746-1596</identifier><identifier>DOI: 10.1186/1746-1596-8-58</identifier><identifier>PMID: 23587357</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adrenal Cortex Neoplasms - chemistry ; Adrenal Cortex Neoplasms - pathology ; Biomarkers ; Biomarkers, Tumor - analysis ; Calreticulin - analysis ; Cancer ; Cell adhesion & migration ; Chaperonin 60 - analysis ; Chi-Square Distribution ; Comparative analysis ; Electrophoresis, Gel, Two-Dimensional ; Health aspects ; Heat shock proteins ; Humans ; Immunohistochemistry ; Mass spectrometry ; Mitochondrial Proteins - analysis ; Neoplasm Staging ; Prognosis ; Protein binding ; Proteins ; Proteomics - methods ; Repressor Proteins - analysis ; Reproducibility of Results ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Studies ; Up-Regulation</subject><ispartof>Diagnostic pathology, 2013-04, Vol.8 (1), p.58-58, Article 58</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Yang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Yang et al.; licensee BioMed Central Ltd. 2013 Yang et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b543t-190310803a789efc4f17f05fe85990575c4facda4dbe2dbb59b8e9a62cb44ee53</citedby><cites>FETCH-LOGICAL-b543t-190310803a789efc4f17f05fe85990575c4facda4dbe2dbb59b8e9a62cb44ee53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640901/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640901/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23587357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Ming-shan</creatorcontrib><creatorcontrib>Wang, Huan-sheng</creatorcontrib><creatorcontrib>Wang, Bao-sheng</creatorcontrib><creatorcontrib>Li, Wan-hu</creatorcontrib><creatorcontrib>Pang, Zeng-fen</creatorcontrib><creatorcontrib>Zou, Ben-kui</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Shi, Xue-tao</creatorcontrib><creatorcontrib>Mu, Dian-bin</creatorcontrib><creatorcontrib>Zhang, De-xian</creatorcontrib><creatorcontrib>Gao, Yong-sheng</creatorcontrib><creatorcontrib>Sun, Xiao-wen</creatorcontrib><creatorcontrib>Xia, Shu-jie</creatorcontrib><title>A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas</title><title>Diagnostic pathology</title><addtitle>Diagn Pathol</addtitle><description>Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was to compare the proteomic profiles between adrenocortical carcinomas (ACC) and normal adrenocortical tissues in order to identify novel potential biomarkers for ACC.
The protein samples from 12 ACC tissues and their paired adjacent normal adrenocortical tissues were profiled with two-dimensional electrophoresis; and differentially expressed proteins were identified by mass spectrometry. Expression patterns of three differently expressed proteins calreticulin, prohibitin and HSP60 in ACC, adrenocortical adenomas (ACA) and normal adrenocortical tissues were further validated by immunohistochemistry.
In our proteomic study, we identified 20 up-regulated and 9 down-regulated proteins in ACC tissues compared with paired normal controls. Most of the up-regulated proteins were focused in protein binding and oxidoreductase activity in Gene Ontology (GO) molecular function classification. By immunohistochemistry, two biomarkers calreticulin and prohibitin were validated to be overexpressed in ACC compared with adrenocortical adenomas (ACA) and normal tissues, but also calreticulin overexpression was significantly associated with tumor stages of ACC.
For the first time, calreticulin and prohibitin were identified to be novel candidate biomarkers for ACC, and their roles during ACC carcinogenesis and clinical significance deserves further investigation.
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1897372598927465.</description><subject>Adrenal Cortex Neoplasms - chemistry</subject><subject>Adrenal Cortex Neoplasms - pathology</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Calreticulin - analysis</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Chaperonin 60 - analysis</subject><subject>Chi-Square Distribution</subject><subject>Comparative analysis</subject><subject>Electrophoresis, Gel, Two-Dimensional</subject><subject>Health aspects</subject><subject>Heat shock proteins</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mass spectrometry</subject><subject>Mitochondrial Proteins - analysis</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Proteomics - methods</subject><subject>Repressor Proteins - analysis</subject><subject>Reproducibility of Results</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Studies</subject><subject>Up-Regulation</subject><issn>1746-1596</issn><issn>1746-1596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kk1rHSEUhqW0NGnabZdloOtJ9aozuilcQr8g0E27Fj-ON4YZnaoTyL-vQ9LbhKa4UM95zss5ryL0luBzQsTwgYxs6AmXQy96Lp6h02Pg-YPzCXpVyjXGjPMdfolOdpSLkfLxFMV9Z9O86KxruIFuyalCmoPtSl3dbRccxBp8ANdZPWWowa5TiJ2ObmOvggm1Xdelz3BYJ10buKVdhphsyo3XUyvNNsQ06_IavfB6KvDmfj9DPz9_-nHxtb_8_uXbxf6yN5zR2hOJKcECUz0KCd4yT0aPuQfBpcR85C2irdPMGdg5Y7g0AqQedtYwBsDpGfp4p7usZgZn2xRZT2rJYdb5ViUd1ONMDFfqkG4UHRiWmDSB_Z2ACek_Ao8zzUW1-a02v5VQXDSN9_dN5PRrhVLVdVpzbHMrQtk4DJLK8S910BOoEH1qenYOxao9bxjmRA6NOn-CastBe60UwYcWf6rA5lRKBn_snWC1fZ1_u3330LIj_uev0N9XecHy</recordid><startdate>20130415</startdate><enddate>20130415</enddate><creator>Yang, Ming-shan</creator><creator>Wang, Huan-sheng</creator><creator>Wang, Bao-sheng</creator><creator>Li, Wan-hu</creator><creator>Pang, Zeng-fen</creator><creator>Zou, Ben-kui</creator><creator>Zhang, Xin</creator><creator>Shi, Xue-tao</creator><creator>Mu, Dian-bin</creator><creator>Zhang, De-xian</creator><creator>Gao, Yong-sheng</creator><creator>Sun, Xiao-wen</creator><creator>Xia, Shu-jie</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130415</creationdate><title>A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas</title><author>Yang, Ming-shan ; Wang, Huan-sheng ; Wang, Bao-sheng ; Li, Wan-hu ; Pang, Zeng-fen ; Zou, Ben-kui ; Zhang, Xin ; Shi, Xue-tao ; Mu, Dian-bin ; Zhang, De-xian ; Gao, Yong-sheng ; Sun, Xiao-wen ; Xia, Shu-jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b543t-190310803a789efc4f17f05fe85990575c4facda4dbe2dbb59b8e9a62cb44ee53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adrenal Cortex Neoplasms - chemistry</topic><topic>Adrenal Cortex Neoplasms - pathology</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Calreticulin - analysis</topic><topic>Cancer</topic><topic>Cell adhesion & migration</topic><topic>Chaperonin 60 - analysis</topic><topic>Chi-Square Distribution</topic><topic>Comparative analysis</topic><topic>Electrophoresis, Gel, Two-Dimensional</topic><topic>Health aspects</topic><topic>Heat shock proteins</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mass spectrometry</topic><topic>Mitochondrial Proteins - analysis</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Protein binding</topic><topic>Proteins</topic><topic>Proteomics - methods</topic><topic>Repressor Proteins - analysis</topic><topic>Reproducibility of Results</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Studies</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Ming-shan</creatorcontrib><creatorcontrib>Wang, Huan-sheng</creatorcontrib><creatorcontrib>Wang, Bao-sheng</creatorcontrib><creatorcontrib>Li, Wan-hu</creatorcontrib><creatorcontrib>Pang, Zeng-fen</creatorcontrib><creatorcontrib>Zou, Ben-kui</creatorcontrib><creatorcontrib>Zhang, Xin</creatorcontrib><creatorcontrib>Shi, Xue-tao</creatorcontrib><creatorcontrib>Mu, Dian-bin</creatorcontrib><creatorcontrib>Zhang, De-xian</creatorcontrib><creatorcontrib>Gao, Yong-sheng</creatorcontrib><creatorcontrib>Sun, Xiao-wen</creatorcontrib><creatorcontrib>Xia, Shu-jie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diagnostic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Ming-shan</au><au>Wang, Huan-sheng</au><au>Wang, Bao-sheng</au><au>Li, Wan-hu</au><au>Pang, Zeng-fen</au><au>Zou, Ben-kui</au><au>Zhang, Xin</au><au>Shi, Xue-tao</au><au>Mu, Dian-bin</au><au>Zhang, De-xian</au><au>Gao, Yong-sheng</au><au>Sun, Xiao-wen</au><au>Xia, Shu-jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas</atitle><jtitle>Diagnostic pathology</jtitle><addtitle>Diagn Pathol</addtitle><date>2013-04-15</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>58</spage><epage>58</epage><pages>58-58</pages><artnum>58</artnum><issn>1746-1596</issn><eissn>1746-1596</eissn><abstract>Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was to compare the proteomic profiles between adrenocortical carcinomas (ACC) and normal adrenocortical tissues in order to identify novel potential biomarkers for ACC.
The protein samples from 12 ACC tissues and their paired adjacent normal adrenocortical tissues were profiled with two-dimensional electrophoresis; and differentially expressed proteins were identified by mass spectrometry. Expression patterns of three differently expressed proteins calreticulin, prohibitin and HSP60 in ACC, adrenocortical adenomas (ACA) and normal adrenocortical tissues were further validated by immunohistochemistry.
In our proteomic study, we identified 20 up-regulated and 9 down-regulated proteins in ACC tissues compared with paired normal controls. Most of the up-regulated proteins were focused in protein binding and oxidoreductase activity in Gene Ontology (GO) molecular function classification. By immunohistochemistry, two biomarkers calreticulin and prohibitin were validated to be overexpressed in ACC compared with adrenocortical adenomas (ACA) and normal tissues, but also calreticulin overexpression was significantly associated with tumor stages of ACC.
For the first time, calreticulin and prohibitin were identified to be novel candidate biomarkers for ACC, and their roles during ACC carcinogenesis and clinical significance deserves further investigation.
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1897372598927465.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23587357</pmid><doi>10.1186/1746-1596-8-58</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenal Cortex Neoplasms - chemistry Adrenal Cortex Neoplasms - pathology Biomarkers Biomarkers, Tumor - analysis Calreticulin - analysis Cancer Cell adhesion & migration Chaperonin 60 - analysis Chi-Square Distribution Comparative analysis Electrophoresis, Gel, Two-Dimensional Health aspects Heat shock proteins Humans Immunohistochemistry Mass spectrometry Mitochondrial Proteins - analysis Neoplasm Staging Prognosis Protein binding Proteins Proteomics - methods Repressor Proteins - analysis Reproducibility of Results Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Studies Up-Regulation |
| title | A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas |
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