An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation

The isocitrate dehydrogenases (ICDs) catalyse the oxidative decarboxylation of isocitrate to alpha-ketoglutarate and can use either NAD+ or NADP+ as a cofactor. Recent studies demonstrate that the NADP+-dependent isocitrate dehydrogenase, as a source of electrons for cellular antioxidants, is import...

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Veröffentlicht in:	Free radical research 2008-07, Vol.42 (7), p.618-624
Hauptverfasser:	Batinic-Haberle, Ines, Benov, Ludmil T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitate Hydratase - metabolism Animals diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Enzyme Activation Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Free Radical Scavengers - pharmacology Isocitrate Dehydrogenase - biosynthesis Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism Isocitrate dehydrogenase inactivation Male manganese porphyrin Metalloporphyrins - pharmacology MnTM-2-PyP Myocardium - enzymology Oxidation-Reduction Oxidative Stress - drug effects Protein Biosynthesis Rats Rats, Wistar Reactive Nitrogen Species - metabolism SOD mimic Superoxide Dismutase - deficiency Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxides - metabolism Time Factors
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